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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Yuhao Zhao1, Xuejie Yu2, Manpreet Saini3, Yanxu Ma4, Rajesh K. Singh3

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Highly Efficient Zinc Oxide Nanoparticles Catalyzed Green Synthesis of 1,5-Benzodiazepines under Solvent-Free Path

https://doi.org/10.14233/ajchem.2014.18319
Yuhao Zhao1
1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China 2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China 3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India 4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China *Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com
Xuejie Yu2
1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China 2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China 3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India 4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China *Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com
Manpreet Saini3
1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China 2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China 3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India 4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China *Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com
Yanxu Ma4
1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China 2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China 3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India 4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China *Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com
Rajesh K. Singh3
1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China 2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China 3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India 4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China *Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com

Corresponding Author(s) : Yuhao Zhao1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

An efficient and simple environment-friendly method for the preparation of substituted 1,5-benzodiazepines as biologically interesting compounds under heterogenous catalyst is described. The one-pot multicomponent condensation of o-phenylene-diamine and substituted ketones catalyzed by zinc oxide nanoparticles (ZnO NPs) under microwave under solvent-free condition has been developed. The present protocol provides a green and improved pathway for the synthesis of 1,5-benzodiazepines in terms of excellent yields, short reaction times and reusability of catalyst.

Keywords

1 5-Benzodiazepines Zinc oxide nanoparticles Heterogenous catalyst.
Zhao1, Y., Yu2, X., Saini3, M., Ma4, Y., & K. Singh3, R. (2014). Highly Efficient Zinc Oxide Nanoparticles Catalyzed Green Synthesis of 1,5-Benzodiazepines under Solvent-Free Path. Asian Journal of Chemistry, 26(24), 8539–8542. https://doi.org/10.14233/ajchem.2014.18319
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