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Vol. 26 No. 24 (2014)

Copyright (c) 2014 M.A. Bhat1, H.A. Ghabbour1, C.S.C. Kumar2, H.K. Fun1

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New and Efficient Synthesis of N-(4-Substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amines

https://doi.org/10.14233/ajchem.2014.18067
M.A. Bhat1
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2X-Ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia *Corresponding author: Fax: +966 1 4676220; Tel: +966 14677343; E-mail: mashooqbhat@rediffmail.com
H.A. Ghabbour1
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2X-Ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia *Corresponding author: Fax: +966 1 4676220; Tel: +966 14677343; E-mail: mashooqbhat@rediffmail.com
C.S.C. Kumar2
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2X-Ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia *Corresponding author: Fax: +966 1 4676220; Tel: +966 14677343; E-mail: mashooqbhat@rediffmail.com
H.K. Fun1
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2X-Ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia *Corresponding author: Fax: +966 1 4676220; Tel: +966 14677343; E-mail: mashooqbhat@rediffmail.com

Corresponding Author(s) : M.A. Bhat1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

The reaction of 2-isonicotinoyl-N-arylhydrazinecarbothioamide (2a-c) with chloroacetic acid in presence of anhydrous sodium acetate in absolute ethanol yields, in each case, a single product. The single crystal X-ray analysis confirmed the structure of these products as N-(4-aryl)-5-(pyridine-4-yl)-1,3,4-oxadiazol-2-amines (4a-c).

Keywords

Isoniazid 1 3 4-oxadiazole X-ray diffraction Crystal structure and packing.
Bhat1, M., Ghabbour1, H., Kumar2, C., & Fun1, H. (2014). New and Efficient Synthesis of N-(4-Substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amines. Asian Journal of Chemistry, 26(24), 8483–8487. https://doi.org/10.14233/ajchem.2014.18067
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