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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Aisha S.M. Hossan1, Abd El-Galil E. Amr2

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Antimicrobial and Pharmacological Activities of Some 3-Substituted Thieno[3,2-d]-pyrimidin-4(3H)-one

https://doi.org/10.14233/ajchem.2014.17922
Aisha S.M. Hossan1
1Chemistry Department, Girls College of Science, King Khalid University, Abha, Saudi Arabia 2Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: hossanaisha@yahoo.com
Abd El-Galil E. Amr2
1Chemistry Department, Girls College of Science, King Khalid University, Abha, Saudi Arabia 2Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 3Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt *Corresponding author: E-mail: hossanaisha@yahoo.com

Corresponding Author(s) : Aisha S.M. Hossan1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

A series of new 3-substituted-7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2- methylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one derivatives (3-10) were synthesized using 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(aryl)-2-methyl-4H-pyrido-[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one (2a,b) as a starting material. All the newly synthesized compounds were evaluated for their antimicrobial activities. The antimicrobial screening showed that many of these obtained compounds have good antimicrobial activities comparable to streptomycin and fusidic acid as reference drugs. Also, the pharmacological screening showed that many compounds have good analgesic and antiparkinsonian activities comparable to Valdecoxib® and Benzotropine® as reference drugs. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral data and elemental analysis.

Keywords

Oxazinone Thienopyrimidine Schiff base Imide derivatives Antimicrobial and pharmacological agents.
S.M. Hossan1, A., & El-Galil E. Amr2, A. (2014). Antimicrobial and Pharmacological Activities of Some 3-Substituted Thieno[3,2-d]-pyrimidin-4(3H)-one. Asian Journal of Chemistry, 26(24), 8436–8444. https://doi.org/10.14233/ajchem.2014.17922
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