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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Sayeed Mukhtar1, Waleed Atef Manasreh1, Humaira Parveen1, Amir Azam2

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Synthesis, Characterization, Antiamoebic Activity and Toxicity of Ferrocenyl Chalcones

https://doi.org/10.14233/ajchem.2014.17697
Sayeed Mukhtar1
1Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia 2Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi-110 025, India *Corresponding author: Tel: +966 550921699; E-mail: sayeed_mukhtar@hotmail.com
Waleed Atef Manasreh1
1Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia 2Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi-110 025, India *Corresponding author: Tel: +966 550921699; E-mail: sayeed_mukhtar@hotmail.com
Humaira Parveen1
1Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia 2Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi-110 025, India *Corresponding author: Tel: +966 550921699; E-mail: sayeed_mukhtar@hotmail.com
Amir Azam2
1Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia 2Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi-110 025, India *Corresponding author: Tel: +966 550921699; E-mail: sayeed_mukhtar@hotmail.com

Corresponding Author(s) : Sayeed Mukhtar1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

Two series of ferrocenyl chalcones were synthesized and evaluated for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. The results showed that compounds of series B having ferrocene ring adjacent to carbonyl linkage were generally more active than compounds of series A. Compounds having unsubstituted phenyl ring, methoxy substitution, thiomethyl group, chloro group and nitro group, exhibited better antiamoebic activity than the reference drug metronidazole. The toxicological studies of these compounds on human kidney epithelial cell line showed that all compounds were non-toxic. The compound 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (18) was found most active and least toxic among all compounds.

Keywords

Ferrocenyl chalcones Antiamoebic activity Toxicity profile.
Mukhtar1, S., Atef Manasreh1, W., Parveen1, H., & Azam2, A. (2014). Synthesis, Characterization, Antiamoebic Activity and Toxicity of Ferrocenyl Chalcones. Asian Journal of Chemistry, 26(24), 8407–8412. https://doi.org/10.14233/ajchem.2014.17697
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