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Copyright (c) 2014 S.M. Yakout1, Ahmed M. Isa3
This work is licensed under a Creative Commons Attribution 4.0 International License.
Investigation of Synthetic Musks Fragrances Pollutants in Human Breast Milk
Corresponding Author(s) : S.M. Yakout1
Asian Journal of Chemistry,
Vol. 26 No. 24 (2014)
Abstract
Synthetic musks, including nitro musks and polycyclic musks are widely used in a variety of personal care and cleaning products as fragrance ingredients. Synthetic musks have been reported to be ubiquitously present in the environment and can accumulate in animal and human tissues owing to their lipophilic nature. Recently, as a result of the potential toxicity of synthetic musks observed in both in vivo and in vitro studies, human exposure to these compounds has been a great concern. Synthetic musks are detected in human maternal blood, breast milk and adipose tissue samples. Human milk is extensively used for identifying and monitoring the body burden of lipophilic and persistent environmental pollutants due to great samples volumes can be collected non-invasively compared with blood and adipose tissue. Additionally, the concentrations of organic pollutants in human milk can reflect the exposure levels of breastfed infants, as well as the contamination status of the local environment. A lot of information already exists on regulated contaminants and human health. but there is less information on the influence of the synthetic musks fragrances on human. For this reason it is presume that this work is timely due to increased interest in the last years to bridge human health with environmental contamination especially synthetic musks. The establishment of relationships between human health and levels of some of these emerging contaminants in human milk is taking place at global scale.
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- R.J. Law, C.R. Allchin, J. de Boer, A. Covaci, D. Herzke, P. Lepom, S. Morris, J. Tronczynski and C.A. de Wit, Chemosphere, 64, 187 (2006).
- R. Guo, I.-S. Lee, U.-J. Kim and J.-E. Oh, Sci. Total Environ., 408, 1634 (2010).
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- IFRA Standard 47th Amendment, Available online (2013).
- J.L. Reiner, C.M. Wong, K.F. Arcaro and K. Kannan, Environ. Sci. Technol., 41, 3815 (2007).
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- J. Yin, H. Wang, J. Zhang, N. Zhou, F. Gao, Y. Wu, J. Xiang and B. Shao, Chemosphere, 87, 1018 (2012).
- X. Zhang, G. Liang, X. Zeng, J. Zhou, G. Sheng and J. Fu, J. Environ. Sci. (China), 23, 983 (2011).
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R. Guo, I.-S. Lee, U.-J. Kim and J.-E. Oh, Sci. Total Environ., 408, 1634 (2010).
L. Roosens, A. Covaci and H. Neels, Chemosphere, 69, 1540 (2007).
U. Klaschka and M. Kolossa-Gehring, Environ. Sci. Pollut. Res. Int., 14(Suppl 1), 44 (2007).
J.L. Reiner and K. Kannan, Chemosphere, 62, 867 (2006).
H. Nakata, Environ. Sci. Technol., 39, 3430 (2005).
R.H.M.M. Schreurs, M.E. Quaedackers, W. Seinen and B. van der Burg, Toxicol. Appl. Pharmacol., 183, 1 (2002).
D. Salvito, Environ. Health Perspect., 113, A802 (2005).
B. Rebhan, M. Kohlhuber, U. Schwegler, B.V. Koletzko and H. Fromme, J. Pediatr. Gastroenterol. Nutr., 49, 467 (2009).
K.-W. Schramm, A. Kaune, B. Beck, W. Thumm, A. Behechti, A. Kettrup and P. Nickolova, Water Res., 30, 2247 (1996).
G. Rimkus, Synthetic Musk Fragrances in the Environment, Springer-Verlag, Berlin-Hei-Delberg-New York, New York (2004).
T. Luckenbach and D. Epel, Environ. Health Perspect., 113, 17 (2004).
S. Tanabe, Mar. Pollut. Bull., 50, 1025 (2005).
A.M. Peck and K.C. Hornbuckle, Environ. Sci. Technol., 38, 367 (2004).
IFRA Standard 47th Amendment, Available online (2013).
J.L. Reiner, C.M. Wong, K.F. Arcaro and K. Kannan, Environ. Sci. Technol., 41, 3815 (2007).
G.G. Rimkus, Toxicol. Lett., 111, 37 (1999).
Z. Hu, Y. Shi, S. Zhang, H. Niu and Y. Cai, Bull. Environ. Contam. Toxicol., 86, 302 (2011).
M.J. Benotti, R.A. Trenholm, B.J. Vanderford, J.C. Holady, B.D. Stanford and S.A. Snyder, Environ. Sci. Technol., 43, 597 (2009).
K. Bester, J. Environ. Monit., 7, 43 (2005).
R. Kallenborn, R. Gatermann, T. Nygard, J. Knutzen and M. Schlabach, Fresenius Environ. Bull., 10, 832 (2001).
A.M. DiFrancesco, P.C. Chiu, L.J. Standley, H.E. Allen and D.T. Salvito, Environ. Sci. Technol., 38, 194 (2004).
J.L. Stevens, G.L. Northcott, G.A. Stern, G.T. Tomy and K.C. Jones, Environ. Sci. Technol., 37, 462 (2003).
H. Fromme, T. Lahrz, M. Piloty, H. Gebhart, A. Oddoy and H. Ruden, Indoor Air, 14, 188 (2004).
S. Muller, P. Schmid and C. Schlatter, Chemosphere, 33, 17 (1996).
R. Kallenborn and R. Gatermann, Synthetic Musks in Ambient and Indoor Air, In: Handbook of Environmental Chemistry, Spring Heidelberg, p. 85-104 (2004).
B. Werner, Synthetic Musks in House Dust, In: Handbook of Environ-mental Chemistry, Springer, Heidelberg, p. 105-121 (2004).
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Scientific Committee on Health and Environmental Risks, Opinion on Classification of Musk Ketone, (SCHER) (2006).
L.D. Lehman-McKeeman, D. Caudill, J.D. Vassallo, R.E. Pearce, A. Madan and A. Parkinson, Toxicol. Lett., 111, 105 (1999).
European Commission, Summary Risk Assessment Report on (4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone) Musk Ketone (2005); http://esis.jrc.ec.europa.eu.
S. Eisenhardt, B. Runnebaum, K. Bauer and I. Gerhard, Environ. Res., 87, 123 (2001).
N. Bitsch, C. Dudas, W. Körner, K. Failing, S. Biselli, G. Rimkus and H. Brunn, Arch. Environ. Contam. Toxicol., 43, 257 (2002).
L. Wollenberger, M. Breitholtz, K. Ole Kusk and B.-E. Bengtsson, Sci. Total Environ., 305, 53 (2003).
B. van der Burg, R. Schreurs, S. van der Linden, W. Seinen, A. Brouwer and E. Sonneveld, Int. J. Androl., 31, 188 (2008).
G. Carlsson and L. Norrgren, Arch. Environ. Contam. Toxicol., 46, 102 (2004).
European Commission, Summary Risk Assessment Report on (1,3,4,6, 7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-g-2-benzopyran) HHCB (2008): http://esis.jrc.ec.europa.eu.
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European Commission, Summary Risk Assessment Report 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl ethane-1-one) AHTN, (2008); http://esis.jrc.ec.europa.eu.
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OSPAR, OSPAR Background Document on Musk Xylene and Other Musks, OSPAR Commission (2004).
WHO, Biomonitoring of Human Milk for Persistent Organic Pollutants (POPs) (2009).
D. Costopoulou, I. Vassiliadou, A. Papadopoulos, V. Makropoulos and L. Leondiadis, Chemosphere, 65, 1462 (2006).
G.M. Solomon and P.M. Weiss, Environ. Health Perspect., 110, A339 (2002).
C.S. Kang, J.-H. Lee, S.-K. Kim, K.-T. Lee, J.S. Lee, P.S. Park, S.H. Yun, K. Kannan, Y.W. Yoo, J.Y. Ha and S.W. Lee, Chemosphere, 80, 116 (2010).
S. Lignell, P.O. Darnerud, M. Aune, S. Cnattingius, J. Hajslova, L. Setkova and A. Glynn, Environ. Sci. Technol., 42, 6743 (2008).
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X. Zhang, G. Liang, X. Zeng, J. Zhou, G. Sheng and J. Fu, J. Environ. Sci. (China), 23, 983 (2011).