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Vol. 26 No. 24 (2014)

Copyright (c) 2014 Alia Erum1, Sajid Bashir1, Shazia Saghir2, Sadia Hina1, Amna Batool1, Tahir Mahmood3

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Arabinoxylan Isolated from Ispaghula Husk: A Better Alternative to Commercially Available Gelling Agents

https://doi.org/10.14233/ajchem.2014.17495
Alia Erum1
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com
Sajid Bashir1
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com
Shazia Saghir2
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com
Sadia Hina1
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com
Amna Batool1
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com
Tahir Mahmood3
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan 2Department of Chemistry, Government Jinnah Degree College for Women, Mozang, Lahore, Pakistan 3Department of Statistics, University of Sargodha, Sargodha, Pakistan *Corresponding author: Fax: +92 48 9230507; Tel: +92 48 3220455; E-mail:alia_erum@hotmail.com

Corresponding Author(s) : Alia Erum1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

Gelling behaviour of a polysaccharide arabinoxylan isolated from Ispaghula, Plantago ovata was investigated and effect of different factors such as concentration of gelling agent, temperature, pH and compatibility with solvents were also studied. Medicated paracetamol and acelofenac gel were formulated by using arabinoxylan as gelling agent. These gels were evaluated for rheological estimation, appearance, stability and compatibility studies and pharmacological effects. Arabinoxylan gelation was pH dependent, rapid gelation (less gelation time) at basic pH with very viscous gel, while at acidic pH (3) low viscosity gel was formed after 48 h. Similarly heating facilitates gelation by reducing gelation time. Arabinoxylan gel was compatible with water, 1 % propylene glycol and ethanol (30 %) while it was incompatible with 70 and 90 % ethanol. Paracetamol (oral) and acelofenac (topical) gels, containing arabinoxylan as gelling agent were homogenous, stable and showed pharmacological effects comparable to gels formulated with HPMC and tragacanth as gelling agent.

Keywords

Arabinoxylan Gelling agent Paracetamol Acelofenac.
Erum1, A., Bashir1, S., Saghir2, S., Hina1, S., Batool1, A., & Mahmood3, T. (2014). Arabinoxylan Isolated from Ispaghula Husk: A Better Alternative to Commercially Available Gelling Agents. Asian Journal of Chemistry, 26(24), 8366–8370. https://doi.org/10.14233/ajchem.2014.17495
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