Issue

Vol. 26 No. 24 (2014)

Copyright (c) 2014 Tiegang Ren1, Jie Wang1, Guihui Li2, Yongzhe Li1

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and in vitro Antitumor Activity of Novel Schiff Bases Containing Pyrazole Group

https://doi.org/10.14233/ajchem.2014.16893
Tiegang Ren1
1Fine Chemistry and Engineering Research Institute, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P.R. China 2Key Laboratory of Ministry of Education for Special Functional Materials, Henan University, Kaifeng 475004, P.R. China *Corresponding author: Tel: +86 378 2866141; E-mail: rtg@henu.edu.cn
Jie Wang1
1Fine Chemistry and Engineering Research Institute, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P.R. China 2Key Laboratory of Ministry of Education for Special Functional Materials, Henan University, Kaifeng 475004, P.R. China *Corresponding author: Tel: +86 378 2866141; E-mail: rtg@henu.edu.cn
Guihui Li2
1Fine Chemistry and Engineering Research Institute, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P.R. China 2Key Laboratory of Ministry of Education for Special Functional Materials, Henan University, Kaifeng 475004, P.R. China *Corresponding author: Tel: +86 378 2866141; E-mail: rtg@henu.edu.cn
Yongzhe Li1
1Fine Chemistry and Engineering Research Institute, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P.R. China 2Key Laboratory of Ministry of Education for Special Functional Materials, Henan University, Kaifeng 475004, P.R. China *Corresponding author: Tel: +86 378 2866141; E-mail: rtg@henu.edu.cn

Corresponding Author(s) : Tiegang Ren1

Asian Journal of Chemistry, Vol. 26 No. 24 (2014)

Abstract

A series of novel Schiff base compounds containing pyrazole group were synthesized with pyrazole aldehyde and benzene hydrazine or pyrazole aldehyde and phenylhydrazine hydrochloride as the starting materials. As-synthesized Schiff base compounds were characterized by means of nuclear magnetic resonance spectroscopy, infrared spectrometry, mass spectrometry and elemental analysis. Moreover the in vitro antitumor activity of compounds B2 and B4 against K562 (human leukemia cell line) was evaluated using MTT assay method. Results show that the compounds can inhibit K562 tumor cell's growth and generation.

Keywords

Schiff base Synthesis Characterize in vitro Antitumor activity Heterocyclic compounds Pyrazole group.
Ren1, T., Wang1, J., Li2, G., & Li1, Y. (2014). Synthesis, Characterization and in vitro Antitumor Activity of Novel Schiff Bases Containing Pyrazole Group. Asian Journal of Chemistry, 26(24), 8309–8313. https://doi.org/10.14233/ajchem.2014.16893
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