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Copyright (c) 2014 Limei Li, Huan Wang, Juanxia Yang, Jie Lou, Guiyou Liu, Xuemei Gao, Qiufen Hu, Yanqing Ye*
This work is licensed under a Creative Commons Attribution 4.0 International License.
A New Dihydroxanthenone from the Fermentation Products of Endophytic Fungus of Phomopsis amygdali
Corresponding Author(s) : Limei Li
Asian Journal of Chemistry,
Vol. 26 No. 24 (2014)
Abstract
A new dihydroxanthone, (1R,2R)-2-hydroxy-6-(hydroxymethyl)-8-methoxy-9-oxo-2,9-dihydro-1H- xanthene-1-carboxylic acid (1) was isolated from the fermentation products of a Phomopsis fungus. Its structure was elucidated by spectroscopic methods. Compound 1 was tested for its cytotoxicity and it showed high cytotoxicity against NB4 and PC3 cell with IC50 values of 4.5 and 3.8 μM.
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D. Udayanga, X. Liu, E.H.C. McKenzie, E. Chukeatirote, A.H.A. Bahkali and K.D. Hyde, Fungal Divers., 50, 189 (2011).
J.N. Choi, J. Kim, K. Ponnusamy, C. Lim, J.G. Kim, M.J. Muthaiya and C.H. Lee, J. Antibiot, 66, 231 (2013).
H. Hussain, M.K. Tchimene, I.K. Ahmed, M. Steinert, S. Draeger, B. Schulz and K. Krohn, Nat. Prod. Commun, 6, 1905 (2011).
H. Hussain, I. Ahmed, B. Schulz, S. Draeger and K. Krohn, Fitoterapia, 83, 523 (2012).
H. Hussain, K. Krohn, I. Ahmed, S. Draeger, B. Schulz, S. Di Pietro and G. Pescitelli, Eur. J. Org. Chem., 1783 (2012).
M. Isaka, A. Jaturapat, K. Rukseree, K. Danwisetkanjana, M. Tanticharoen and Y. Thebtaranonth, J. Nat. Prod., 64, 1015 (2001).
C. Hemtasin, S. Kanokmedhakul, K. Kanokmedhakul, C. Hahnvajanawong, K. Soytong, S. Prabpai and P. Kongsaeree, J. Nat. Prod., 74, 609 (2011).
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K.S. Masters and S. Brase, Chem. Rev., 112, 3717 (2012).
S. Kaul, S. Gupta, M. Ahmed and M.K. Dhar, Phytochem. Rev., 11, 487 (2012).
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