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Vol. 26 No. 23 (2014)

Copyright (c) 2014 Hassan M. Faidallah*, Alaa A. Saqer, Khalid. A. Alamry, Khalid A. Khan, Mohie A.M. Zayed, Salman A. Khan

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Design, Synthesis and Biological Evaluation of Some Novel Hexahydroquinoline-3-carbonitriles as Anticancer and Antimicrobial Agents

https://doi.org/10.14233/ajchem.2014.17616
Hassan M. Faidallah*
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com
Alaa A. Saqer
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com
Khalid. A. Alamry
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com
Khalid A. Khan
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com
Mohie A.M. Zayed
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com
Salman A. Khan
Department of Chemistry, P O Box 80203, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia *Corresponding author: Tel: +966 567743180; E-mail: hfaidallahm@hotmail.com

Corresponding Author(s) : Hassan M. Faidallah*

Asian Journal of Chemistry, Vol. 26 No. 23 (2014)

Abstract

The synthesis of ten novel 3-cyano-8-methyl-2-oxo-1,4-disubstituted-1,2,5,6,7,8-hexahydro-quinolines supported with benzensulfonyl and phenylthiocarbamoyl pharmacophores that are known to contribute to potential chemotherapeutic effects is described. They were evaluated in vitro for their antimicrobial activity against eight different microorganisms and for their cytotoxic effects against three different human tumor cell lines. The results revealed that nine compounds displayed variable inhibitory effects on the growth of the tested Gram-positive and Gram-negative bacteria with special pronounced activity against S. aureus and E. coli bacterial strains, in addition to a moderate antifungal activity against C. albicans. On the other hand, six compounds were able show remarkable cytotoxic efficiency against human colon carcinoma HT29, hepatocellular carcinoma Hep-G2 and Caucasian breast adenocarcinoma MCF7 cell lines. Collectively, the results would suggest that compounds 15 and 16 could be considered as possible dual antimicrobial-anticancer agents.

Keywords

Synthesis N-benzensulfonyl N-phenylthiocarbamoyl cytotoxic agents antimicrobial agents.
M. Faidallah*, H., A. Saqer, A., A. Alamry, K., A. Khan, K., A.M. Zayed, M., & A. Khan, S. (2014). Design, Synthesis and Biological Evaluation of Some Novel Hexahydroquinoline-3-carbonitriles as Anticancer and Antimicrobial Agents. Asian Journal of Chemistry, 26(23), 8139–8144. https://doi.org/10.14233/ajchem.2014.17616
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