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Copyright (c) 2014 Jing-Jing Shu1, Chuan Zhang2, Ting-Fang Wang2, Hao Zou2, Lei Jin2, Wei-Ying Gu1, Li-Chao Zhang1
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis of Novel Danshensu Alkamine Derivatives as Potential Anti-Myocardial Ischemia Agents
Corresponding Author(s) : Jing-Jing Shu1
Asian Journal of Chemistry,
Vol. 26 No. 23 (2014)
Abstract
Ten novel danshensu alkamine derivatives were synthesized and the preliminary biological activity of these complexes were investigated. The bioassay results indicated that some of derivatives exhibit significant activities on protecting hypoxic H9C2 cardiomyocytes.
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- Z.T. Dong and W.D. Jiang, Acta Pharmacol. Sin., 17, 226 (1982).
- F.F.Y. Lam, J.H.K. Yeung, K.M. Chan and P. Mei Yu Or, Vascul. Pharmacol., 46, 271 (2007).
- C.Z. Li, S.C. Yang, F.D. Zhao, Y.Q. Yang, C.X. Yang and D.C. Zhang, Zhongxiyi Jiehe Zazhi, 3, 297 (1983).
- Z.H. Heng, Y.P. Lou, H.J. Dai and F. Xue, Acta Atadem. Med. ShangHai, 14, 25 (1987).
- L.H. Tang, X.M. Wang and D.Q. Liang, Zhongguo Bingli Shengli Zazhi, 5, 65 (1989).
- X.Y. Le, C.L. Chen, L. Ma, N. Zhao, Y.Q. Tang and X.Q. Liu, Chin. J. Nat. Med., 6, 461 (2008).
- X.Q. Liu, X.T. Luo and X.A. Ouyang, Shizhen Guoyi Guoyao, 12, 474 (2001).
- K. Chan, S.H. Chui, D.Y.L. Wong, W.Y. Ha, C.L. Chan and R.N.S. Wong, Life Sci., 75, 3157 (2004).
- G.R. Zhao, H.M. Zhang, T.X. Ye, Z.J. Xiang, Y.J. Yuan, Z.-X. Guo and L.-B. Zhao, Food Chem. Toxicol., 46, 73 (2008).
- N. Zhang, H. Zou, L. Jin, J. Wang, M.F. Zhong, P. Huang, B.Q. Gu, S.L. Mao, C. Zhang and H. Chen, Acta Pharmacol. Sin., 31, 421 (2010).
- L.M. Zhou, M.S.S. Chow and Z. Zuo, Int. J. Pharm., 379, 109 (2009).
- W.D. Jiang, Y.H. Chen and Y.P. Wang, Acta Acad. Med. Primary ShangHai, 9, 13 (1982).
- J.C. Dong, H.J. Dai, F. Xue, L. Zhu, Y.D. Sao, Q.X. Zhang and G.X. Zhang, Acta Atadem. Med. ShangHai, 14, 447 (1987).
- S.C. Bergmeier, Tetrahedron, 56, 2561 (2000).
- T.F. Wang, J.J. Shu, L.P. Zheng, L.Y. Xiong, J. Wang, L. Jin, Q.Y. Wu, H. Zou and C. Zhang, Lat. Am. J. Pharm., 30, 1355 (2011).
References
Z.T. Dong and W.D. Jiang, Acta Pharmacol. Sin., 17, 226 (1982).
F.F.Y. Lam, J.H.K. Yeung, K.M. Chan and P. Mei Yu Or, Vascul. Pharmacol., 46, 271 (2007).
C.Z. Li, S.C. Yang, F.D. Zhao, Y.Q. Yang, C.X. Yang and D.C. Zhang, Zhongxiyi Jiehe Zazhi, 3, 297 (1983).
Z.H. Heng, Y.P. Lou, H.J. Dai and F. Xue, Acta Atadem. Med. ShangHai, 14, 25 (1987).
L.H. Tang, X.M. Wang and D.Q. Liang, Zhongguo Bingli Shengli Zazhi, 5, 65 (1989).
X.Y. Le, C.L. Chen, L. Ma, N. Zhao, Y.Q. Tang and X.Q. Liu, Chin. J. Nat. Med., 6, 461 (2008).
X.Q. Liu, X.T. Luo and X.A. Ouyang, Shizhen Guoyi Guoyao, 12, 474 (2001).
K. Chan, S.H. Chui, D.Y.L. Wong, W.Y. Ha, C.L. Chan and R.N.S. Wong, Life Sci., 75, 3157 (2004).
G.R. Zhao, H.M. Zhang, T.X. Ye, Z.J. Xiang, Y.J. Yuan, Z.-X. Guo and L.-B. Zhao, Food Chem. Toxicol., 46, 73 (2008).
N. Zhang, H. Zou, L. Jin, J. Wang, M.F. Zhong, P. Huang, B.Q. Gu, S.L. Mao, C. Zhang and H. Chen, Acta Pharmacol. Sin., 31, 421 (2010).
L.M. Zhou, M.S.S. Chow and Z. Zuo, Int. J. Pharm., 379, 109 (2009).
W.D. Jiang, Y.H. Chen and Y.P. Wang, Acta Acad. Med. Primary ShangHai, 9, 13 (1982).
J.C. Dong, H.J. Dai, F. Xue, L. Zhu, Y.D. Sao, Q.X. Zhang and G.X. Zhang, Acta Atadem. Med. ShangHai, 14, 447 (1987).
S.C. Bergmeier, Tetrahedron, 56, 2561 (2000).
T.F. Wang, J.J. Shu, L.P. Zheng, L.Y. Xiong, J. Wang, L. Jin, Q.Y. Wu, H. Zou and C. Zhang, Lat. Am. J. Pharm., 30, 1355 (2011).