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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Lei Bi1, Sheng Fang1, Ran Zhang1, Xianzhen Yin1, Chenchao Fu1, Lei Yao2

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Regioselective Mono-bromination of Pyrrolo[2,1-f][1,2,4]triazin-4-amine

https://doi.org/10.14233/ajchem.2014.17858
Lei Bi1
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com
Sheng Fang1
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com
Ran Zhang1
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com
Xianzhen Yin1
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com
Chenchao Fu1
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com
Lei Yao2
1School of Chemistry and Chemical Engineering, Anhui University of Technology, 59 Hudong Road, Maanshan 243002, Anhui, P.R. China 2School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, Shandong, P.R. China *Corresponding authors: E-mail: lei_bi@hotmail.com; yaoleiytu@163.com

Corresponding Author(s) : Lei Bi1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

Pyrrolo[2,1-f][1,2,4]triazin-4-amine is regioselectively brominated when treated with 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione in different solvents. The brominated product, 5,7-dibromopyrrolo[2,1-f][1,2,4]triazin-4-amine predominates when the reaction is run in dichloromethane. The subsequent debromination process utilizes lithium-bromine exchange to give the desired product 5-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-amine.

Keywords

Over-bromination Lithium-bromine exchange.
Bi1, L., Fang1, S., Zhang1, R., Yin1, X., Fu1, C., & Yao2, L. (2014). Regioselective Mono-bromination of Pyrrolo[2,1-f][1,2,4]triazin-4-amine. Asian Journal of Chemistry, 26(20), 7083–7084. https://doi.org/10.14233/ajchem.2014.17858
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