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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Fei Xiong1, Xiao-Kang Li4, Shu-Ping Zhang1, Xiao-Hong Zhang1, Qian-Yu Yu1, Fei Hu1, Zhan-Qiang Dai1

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This work is licensed under a Creative Commons Attribution 4.0 International License.

An Improved One-Pot Synthesis of Hexamethyleneimine from e-Hexanolactam

https://doi.org/10.14233/ajchem.2014.17613
Fei Xiong1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Xiao-Kang Li4
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Shu-Ping Zhang1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Xiao-Hong Zhang1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Qian-Yu Yu1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Fei Hu1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com
Zhan-Qiang Dai1
1Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China 2Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Shayang, P.R. China 3Department of Chemistry, Fudan University, Shanghai 200043, P.R. China 4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China *Corresponding author: E-mail: fduxiong@gmail.com

Corresponding Author(s) : Fei Xiong1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

A mild and efficient method for the preparation of hexamethyleneimine was achieved via a single one-pot chemoselective reduction of amide group in e-hexanolactam by freshly prepared Al(BH4)3 in THF. This approach provides a facile shortcut for the synthesis of this type of compounds with excellent yields, short reaction time, mild reaction conditions, environmentally friendly method, simple work-up procedure, low-cost and easy operation.

Keywords

e-Hexanolactam e-Caprolactam Hexamethyleneimine Reduction Synthesis.
Xiong1, F., Li4, X.-K., Zhang1, S.-P., Zhang1, X.-H., Yu1, Q.-Y., Hu1, F., & Dai1, Z.-Q. (2014). An Improved One-Pot Synthesis of Hexamethyleneimine from e-Hexanolactam. Asian Journal of Chemistry, 26(20), 7077–7078. https://doi.org/10.14233/ajchem.2014.17613
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