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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Zulfiqar Ali1, Syeda Rubina Gilani1, a Jabeen2, Habib Hussain1, Hajira Rehman3, Imdad Hussain1

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Investigation of Antibacterial Activity of Alanine and Phenylalanine Derived Weinreb Amides Against Different Bacterial Strains

https://doi.org/10.14233/ajchem.2014.17002
Zulfiqar Ali1
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com
Syeda Rubina Gilani1
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com
a Jabeen2
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com
Habib Hussain1
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com
Hajira Rehman3
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com
Imdad Hussain1
1Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan 2Department of Botany, University of Punjab, Lahore, Pakistan 3Department of Chemistry, University of Punjab, Lahore, Pakistan *Corresponding author: Tel: +92 3214947884, E-mail: zulfi_ali_4@yahoo.com

Corresponding Author(s) : Zulfiqar Ali1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

Weinreb amides derived from alanine and phenylalanine were tested against different bacterial strains. Antibacterial activity of weinreb amides were tested on 5 different strains i.e., E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Methicillin-resistant Staphylococcus aureus. The antibacterial activity was evaluated using the Agar ditch method. The Weinreb amides 3, 4 and 5 exhibited good activity against E. coli, Pseudomonas aeruginosa and showed poor results against Staphylococcus aureus, Bacillus subtilis and Methicillin-resistant Staphylococcus aureus. The minimum inhibition concentrations of tested compounds were checked against each bacterial strain and results were recorded.

Keywords

Weinreb amides Antibacterial activity Minimum inhibition concentrations.
Ali1, Z., Rubina Gilani1, S., Jabeen2, a, Hussain1, H., Rehman3, H., & Hussain1, I. (2014). Investigation of Antibacterial Activity of Alanine and Phenylalanine Derived Weinreb Amides Against Different Bacterial Strains. Asian Journal of Chemistry, 26(20), 7067–7068. https://doi.org/10.14233/ajchem.2014.17002
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