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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Farhat Ali Khan1, Sudhair Abbas2, Bashir Ahmad3, Naser M. Abdei-Salam4, Riaz Ullah5

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Study of Cross-Linked Poly(N-vinyl-2-pyrrolidone) Gel and Its Uses in the Controlled Release of Antiinflammatory Drug Diclofenac Sodium

https://doi.org/10.14233/ajchem.2014.17972
Farhat Ali Khan1
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2Department of Pharmacy, Abasyn University, Peshawar, Pakistan 3Centre of Biotechnology and Microbiology, University of Peshawar, Peshwar, Pakistan 4Riyadh Community College, King Saud University, Riyadh 11437, Saudi Arabia 5Department of Chemistry, Government College, Ara Khel FR Kohat,Pakistan *Corresponding author: E-mail: afridiriaz@yahoo.com
Sudhair Abbas2
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2Department of Pharmacy, Abasyn University, Peshawar, Pakistan 3Centre of Biotechnology and Microbiology, University of Peshawar, Peshwar, Pakistan 4Riyadh Community College, King Saud University, Riyadh 11437, Saudi Arabia 5Department of Chemistry, Government College, Ara Khel FR Kohat,Pakistan *Corresponding author: E-mail: afridiriaz@yahoo.com
Bashir Ahmad3
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2Department of Pharmacy, Abasyn University, Peshawar, Pakistan 3Centre of Biotechnology and Microbiology, University of Peshawar, Peshwar, Pakistan 4Riyadh Community College, King Saud University, Riyadh 11437, Saudi Arabia 5Department of Chemistry, Government College, Ara Khel FR Kohat,Pakistan *Corresponding author: E-mail: afridiriaz@yahoo.com
Naser M. Abdei-Salam4
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2Department of Pharmacy, Abasyn University, Peshawar, Pakistan 3Centre of Biotechnology and Microbiology, University of Peshawar, Peshwar, Pakistan 4Riyadh Community College, King Saud University, Riyadh 11437, Saudi Arabia 5Department of Chemistry, Government College, Ara Khel FR Kohat,Pakistan *Corresponding author: E-mail: afridiriaz@yahoo.com
Riaz Ullah5
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2Department of Pharmacy, Abasyn University, Peshawar, Pakistan 3Centre of Biotechnology and Microbiology, University of Peshawar, Peshwar, Pakistan 4Riyadh Community College, King Saud University, Riyadh 11437, Saudi Arabia 5Department of Chemistry, Government College, Ara Khel FR Kohat,Pakistan *Corresponding author: E-mail: afridiriaz@yahoo.com

Corresponding Author(s) : Farhat Ali Khan1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

The objective of present study was to synthesize poly(N-vinyl-2-pyrrolidone) gel with different compositions, characterized and used as carrier for different of drugs. Three formulations with different ratios (drugs-hydrogel ratio 1:1, 1:2 and 1:3) were prepared. The released of drug from hydrogels followed both diffusion and erosion. The hydrogel was compressed with diclofenac sodium at different ratios (drugs-hydrogel ratio 1:1, 1:2 and 1:3). After being compressed, matrix tablets were put into dissolution medium in order to test the release mechanism of diclofenac sodium from compressed tablets and its release time. The sustainability of diclofenac sodium (1:1) was 5.5 h and the drug release from compressed tablets was 92 %. The sustainability of diclofenac sodium (1:2) was 8 h and the drug release from matrix tablets was 85 %. The results obtained at 1:3 showed 77 % of diclofenac sodium was released after 13 h. The present study revealed that drugs and hydrogel at 1:3 was proficient for supporting the diclofenac sodium for longer period of time as compared with other drug/polymer ratios (1:1 and 1:2).

Keywords

Diclofenac sodium Sustained release Poly(N-vinyl-2-pyrrolidone) Hydrogels Dissolution media.
Ali Khan1, F., Abbas2, S., Ahmad3, B., M. Abdei-Salam4, N., & Ullah5, R. (2014). Study of Cross-Linked Poly(N-vinyl-2-pyrrolidone) Gel and Its Uses in the Controlled Release of Antiinflammatory Drug Diclofenac Sodium. Asian Journal of Chemistry, 26(20), 7061–7066. https://doi.org/10.14233/ajchem.2014.17972
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