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Vol. 26 No. 20 (2014)

Copyright (c) 2014 B. Ngameni1, G.W. Fotso2, E. Ngachussi2, H.M. Poumale Poumale2, B.T. Ngadjui2, Y. Shiono3, T. Murayama3

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Hemisynthesis and Spectroscopic Characterization of Two Novel O-Allylated Benzophenones from Garcinia punctata Oliv. (Clusiaceae)

https://doi.org/10.14233/ajchem.2014.17478
B. Ngameni1
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
G.W. Fotso2
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
E. Ngachussi2
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
H.M. Poumale Poumale2
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
B.T. Ngadjui2
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
Y. Shiono3
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp
T. Murayama3
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O. Box. 8664, Yaounde, Cameroon 2Department of Organic Chemistry, Faculty of Science, University of Yaounde-1, P.O. Box. 812, Yaoundé, Cameroon 3Department of Bioresource Engineering, Faculty of Agriculture, Tsuruoka, Yamagata 997-8555, Japan *Corresponding author: E-mail: bath_ngameni@yahoo.fr; mtetsuya@tr.yamagata-u.ac.jp

Corresponding Author(s) : B. Ngameni1

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

Four known natural compounds i.e., (-) isogarcinol, (+) 7-epigarcinol, stigmasterol and b-sitosterol-3-O-b-D-glucoside were isolated from the stem bark of Garcinia punctata oliv. From (-) isogarcinol, two new hemisynthesis O-allylated benzophenones were synthesized using allylbromide in the presence of potassium carbonate in anhydrous acetone. The structural elucidation of all the compounds was done by mass spectrometry, IR, 1D- and 2D-NMR analysis and also by comparison with previous reports. This is the first study to report on the one step allylation of the natural (-) isogarcinol using the base catalysis conditions.

Keywords

Garcinia punctata Clusiaceae (-) Isogarcinol Allylation reaction O-Allylated benzophenones.
Ngameni1, B., Fotso2, G., Ngachussi2, E., Poumale Poumale2, H., Ngadjui2, B., Shiono3, Y., & Murayama3, T. (2014). Hemisynthesis and Spectroscopic Characterization of Two Novel O-Allylated Benzophenones from Garcinia punctata Oliv. (Clusiaceae). Asian Journal of Chemistry, 26(20), 6943–6949. https://doi.org/10.14233/ajchem.2014.17478
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