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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Zulfiqar Ali*, Syeda Rubina Gilani, Habib Hussain, Imdad Hussain

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Conversion of Alanine and Phenylalanine into Weinreb Amides by Using Different Protecting Groups

https://doi.org/10.14233/ajchem.2014.16621
Zulfiqar Ali*
Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan *Corresponding author: Tel: +92 321 4947884; E-mail: zulfi_ali_4@yahoo.com
Syeda Rubina Gilani
Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan *Corresponding author: Tel: +92 321 4947884; E-mail: zulfi_ali_4@yahoo.com
Habib Hussain
Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan *Corresponding author: Tel: +92 321 4947884; E-mail: zulfi_ali_4@yahoo.com
Imdad Hussain
Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan *Corresponding author: Tel: +92 321 4947884; E-mail: zulfi_ali_4@yahoo.com

Corresponding Author(s) : Zulfiqar Ali*

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

Efficient conversions of amino acids into Weinreb amides were achieved by treatment of amino acids with N, O-dimethylhydroxylamine hydrochloride in basic media. The amino group (-NH2) of amino acids were protected with p-toluene sulphonyl chloride (-OTs) and diphenyl phosphinic chloride (-dpp) to get high yield of the product. The products were purified by flash chromatography and characterized by spectroscopic techniques.

Keywords

Weinreb amides p-Toluene sulphonyl chloride Diphenyl phosphinic chloride.
Ali*, Z., Rubina Gilani, S., Hussain, H., & Hussain, I. (2014). Conversion of Alanine and Phenylalanine into Weinreb Amides by Using Different Protecting Groups. Asian Journal of Chemistry, 26(20), 6733–6736. https://doi.org/10.14233/ajchem.2014.16621
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