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Vol. 26 No. 20 (2014)

Copyright (c) 2014 Musa M. Musa

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Enzymatic Production of Both Enantiomers of Rhododendrol

https://doi.org/10.14233/ajchem.2014.16581
Musa M. Musa
Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Kingdom of Saudi Arabia Corresponding author: Fax: +966 138604277; Tel: +966 138607343; E-mail: musam@kfupm.edu.sa

Corresponding Author(s) : Musa M. Musa

Asian Journal of Chemistry, Vol. 26 No. 20 (2014)

Abstract

An asymmetric synthetic approach to produce (R)- and (S)-rhododendrol is described. W110A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (W110A TeSADH), an (S)-specific mutant of TeSADH, is used in this approach. The enantioselective reduction of 4-(4'-hydroxyphenyl)-2-butanone catalyzed by W110A TeSADH yielded (S)-rhododendrol, the Prelog product. The anti-Prelog product, (R)-rhododendrol, is produced from (rac)-rhododendrol through enantiospecific kinetic resolution catalyzed by W110A TeSADH.

Keywords

Alcohol dehydrogenases Asymmetric reduction Biotransformations Kinetic resolution Redox reactions Rhododendrol.
M. Musa, M. (2014). Enzymatic Production of Both Enantiomers of Rhododendrol. Asian Journal of Chemistry, 26(20), 6719–6721. https://doi.org/10.14233/ajchem.2014.16581
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