Issue

Vol. 25 No. 18 (2013)

Transdermal Pharmacokinetics Study of Extracts from Cortex Daphnes

https://doi.org/10.14233/ajchem.2013.15914
Y.J. Cheng1
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com
L. Ma2
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com
Z.P. Wei3
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com
C.H. Yang4
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com
F. Han5
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com
Y.F. Wang6
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China 2Department of Pharmacy, Tianjin Institutes of Pharmaceutical Research, Tianjin, P.R. China 3Department of pharmaceutics, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4H and J Medical Devices Ltd, Tianjin 300384, P.R. China 5Tianjin Institute of Pharmaceutical Research, Tianjin 300193, P.R. China 6School of science, Tianjin University, Tianjin 300072, P.R. China *Corresponding authors: Tel/Fax: +86 22 23006851; E-mail: zhihua504@163.com

Corresponding Author(s) : Y.J. Cheng1

Asian Journal of Chemistry, Vol. 25 No. 18 (2013)

Abstract

Extracts from Cortex Daphnes mainly contain daphnin, daphnetin-8-glucoside and daphnetin with a total proportion of 60 %. The main purpose of this study was to illustrate concentration profile of daphnin, daphnetin-8-glucoside and daphnetin in rabbit plasma after transdermal administration of extracts from Cortex Daphnes. A RP-HPLC method was used for simultaneous determination of the three components with a gradient solvent system. Ferulic acid was used as an internal standard. Sample preparations were carried out by extraction with ethyl acetate and deproteinization with methanol. The pharmacokinetic parameters were computed by software program DAS 2.1.1. Results indicated that blood pharmacokinetics of three compounds fit best to a two-compartment model. The maximum concentration (Cmax) varied due to different components, but the peak time (Tmax) of three compounds was about 0.75 h, indicating a fast absorption after administration.

Keywords

Daphnin Daphnetin-8-glucoside Daphnetin Transdermal Pharmacokinetics.
Cheng1, Y., Ma2, L., Wei3, Z., Yang4, C., Han5, F., & Wang6, Y. (2013). Transdermal Pharmacokinetics Study of Extracts from Cortex Daphnes. Asian Journal of Chemistry, 25(18), 10551–10555. https://doi.org/10.14233/ajchem.2013.15914
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