One-Pot Synthesis of 2-Arylbenzoxazoles Using Cu(OTf)2-Catalyzed Condensation and Oxidative Tandem Reaction

S.Y. Luo1; L.Q. Qin1; K. Wang1; X.X. Liu1; X.H. Yi1

doi:10.14233/ajchem.2013.15513

Issue

Vol. 25 No. 18 (2013)

Issue Published : 2 December 2013

One-Pot Synthesis of 2-Arylbenzoxazoles Using Cu(OTf)2-Catalyzed Condensation and Oxidative Tandem Reaction

https://doi.org/10.14233/ajchem.2013.15513

S.Y. Luo1

1Department of Chemistry and Pharmaceutical Sciences, Guilin Normal College, Guilin 541001, P.R. China 2School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P.R. China *Corresponding authors: Fax: +86 773 5803930; Tel: + 86 773 5846279; E-mail: chemwang2006@aliyun.com; lizhangdong2005@163.com

L.Q. Qin1

K. Wang1

X.X. Liu1

X.H. Yi1

Corresponding Author(s) : S.Y. Luo1

Asian Journal of Chemistry, Vol. 25 No. 18 (2013)
Article Published : 13 December 2013

Abstract

An efficient one-pot condensation and oxidative tandem process has been developed for the synthesis of 2-arylbenzoxazoles derivatives from 2-aminophenols and substituted aldehydes in presence of the catalytic amounts Cu(OTf)₂. Reactions were conducted with short reaction times, ligands free, high conversion, high functional group tolerability and straight forward procedure under reflux conditions in air. This protocol provides a straight-forward approach to synthesize 2-arylbenzoxazoles.

Keywords

Tandem process 2-Arylbenzoxazoles Cu(OTf)2-catalyzed.

Luo1, S., Qin1, L., Wang1, K., Liu1, X., & Yi1, X. (2013). One-Pot Synthesis of 2-Arylbenzoxazoles Using Cu(OTf)2-Catalyzed Condensation and Oxidative Tandem Reaction. Asian Journal of Chemistry, 25(18), 10381–10385. https://doi.org/10.14233/ajchem.2013.15513