1Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
2Department of Drugs Control Administration, Hyderabad-500 038, India
*Corresponding author: E-mail: sunithareddy04@gmail.com
P. Venkateswarlu1
1Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
2Department of Drugs Control Administration, Hyderabad-500 038, India
*Corresponding author: E-mail: sunithareddy04@gmail.com
P.S.S. Prasad2
1Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
2Department of Drugs Control Administration, Hyderabad-500 038, India
*Corresponding author: E-mail: sunithareddy04@gmail.com
A rapid and sensitive method for analysis of azelnidipine in human plasma by ultra-performance liquid chromatography tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, azelnidipine was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility and good linearity of calibration curve in the range of 0.01-10 ng/mL for quality control samples spiked with azelnidipine. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.
Keywords
AzelnidipineEthyl derivative of azelnidipineUPLCHuman plasma.
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Suneetha1, G., Venkateswarlu1, P., & Prasad2, P. (2013). Sensitive Analysis of Azelnidipine and Related Derivative in Human Plasma by Ultra-Performance Liquid Chromatography-Tandam Mass Spectrometry. Asian Journal of Chemistry, 25(18), 10319–10321. https://doi.org/10.14233/ajchem.2013.15290
