Synthesis and Antibacterial Activities of Halogenated Hydroxy Diphenyl Ether Derivatives

Guang Min Chen1; Xiu Yang1; Jian Chun Li2; Kai-Qun Wu1; Yu-Liang Wang1; Tian Chen2

doi:10.14233/ajchem.2013.15254

Issue

Vol. 25 No. 18 (2013)

Issue Published : 2 December 2013

Synthesis and Antibacterial Activities of Halogenated Hydroxy Diphenyl Ether Derivatives

https://doi.org/10.14233/ajchem.2013.15254

Guang Min Chen1

1Faculty of Chemistry, Sichuan University, Chengdu 610065, P.R. China 2Department of Pathogenic Biology, Chengdu Medical College, Chengdu 610083, P.R. China *Corresponding author: Tel: +86 13708058490, E-mail: chemwang2000@163.com

Xiu Yang1

Jian Chun Li2

Kai-Qun Wu1

Yu-Liang Wang1

Tian Chen2

Corresponding Author(s) : Guang Min Chen1

Asian Journal of Chemistry, Vol. 25 No. 18 (2013)
Article Published : 13 December 2013

Abstract

Seven halogenated hydroxy diphenyl ether derivatives have been synthesized, 6 of them are new compounds and their structures were identified by ¹H NMR, HR-MS and IR spectra. The antibacterial activities of all the present compounds were tested via the agar-well diffusion method in vitro in the concentration of 50 μg/mL. The results showed that most of the new compounds exhibited antibacterial activities against the tested bacterium.

Keywords

Hydroxy diphenyl ethers Derivatives Antibacterial activity.

(1)

Min Chen1, G.; Yang1, X.; Chun Li2, J.; Wu1, K.-Q.; Wang1, Y.-L.; Chen2, T. Synthesis and Antibacterial Activities of Halogenated Hydroxy Diphenyl Ether Derivatives. ajc 2013, 25, 10244-10246.