Issue

Vol. 25 No. 18 (2013)

Micronization and Dissolubility of Griseofulvin Using Rapid Expansion of Supercritical Solution with Cosolvent Process

https://doi.org/10.14233/ajchem.2013.15210
Guoqin Hu*
School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, Henan Province, P.R. China *Corresponding author: Tel/Fax: +86 371 67781712; E-mail: huguoqin@zzu.edu.cn
Sujuan Zhang
School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, Henan Province, P.R. China *Corresponding author: Tel/Fax: +86 371 67781712; E-mail: huguoqin@zzu.edu.cn
Banghai Xie
School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, Henan Province, P.R. China *Corresponding author: Tel/Fax: +86 371 67781712; E-mail: huguoqin@zzu.edu.cn

Corresponding Author(s) : Guoqin Hu*

Asian Journal of Chemistry, Vol. 25 No. 18 (2013)

Abstract

Micronization of griseofulvin was prepared using rapid expansion of supercritical solution (RESS) with cosolvent process. The average diameter of precipitated by rapid expansion of supercritical solution was 1 μm or so. The results of SEM and DSC showed that the microparticles in crystal habit were not modified evidently at the experimental conditions tested. The dissolving rate of precipitated particles was enhanced in the buffer solution.

Keywords

Micronization Rapid expansion of supercritical solution Cosolvent Dissolubility Griseofulvin.
Hu*, G., Zhang, S., & Xie, B. (2013). Micronization and Dissolubility of Griseofulvin Using Rapid Expansion of Supercritical Solution with Cosolvent Process. Asian Journal of Chemistry, 25(18), 10157–10159. https://doi.org/10.14233/ajchem.2013.15210
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