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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Synthesis of 1-Alkyl-2-chloromethylbenzimidazole Under Green Conditions

https://doi.org/10.14233/ajchem.2015.16730
S. Srinivas Rao
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering Kukatpally, Hyderabad -500 085, India
Ch. Venkata Ramana Reddy
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering Kukatpally, Hyderabad -500 085, India
P.K. Dubey
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering Kukatpally, Hyderabad -500 085, India

Corresponding Author(s) : S. Srinivas Rao

seenu604@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

A green approach for the synthesis of 1-alkyl-2-chloromethylbenzimidazoles (3) (R1 = CH3, C2H5, CH2Ph) under, different conditions has been developed from 2-chloromethylbenzimidazole (2) by reaction with an alkylating agent (i.e. DMS, DES, PhCH2Cl) by physical grinding or by using green solvent like PEG-600 or by using micro-wave irradiation technique.

Keywords

Green synthesis Grinding Microwave N-alkyl-2-chloromethylbenzimidazole Benzimidazole
Srinivas Rao, S., Venkata Ramana Reddy, C., & Dubey, P. (2014). Synthesis of 1-Alkyl-2-chloromethylbenzimidazole Under Green Conditions. Asian Journal of Chemistry, 27(1), 98–100. https://doi.org/10.14233/ajchem.2015.16730
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