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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Synthesis and Antifungal Activities of Novel Fluorine-Containing Triazole Compounds

https://doi.org/10.14233/ajchem.2015.16839
Shuang-Hua Yang
Department of Environment Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023, P.R. China
Zhi-Wei Zhai
Department of Environment Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023, P.R. China
Shao-Wen Zhang
Department of Environment Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023, P.R. China

Corresponding Author(s) : Zhi-Wei Zhai

zhaizw2005@126.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

A series of novel triazole compounds containing fluorinated arylphenyl ether group were designed and synthesized. Al1 the new compounds were identified by IR, 1H NMR and elemental analysis. Their in vitro antifungal activities against five common pathogens were evaluated by mycelial growth rate method. The preliminary bioassay indicated that all the target compounds possess some fungicidal activities against Gibberella zeae, Alternaria solani, Fusarium oxysporum, Physalospora pircola and Cercospora arachidicola. In particular, compound 5e exhibited excellent antifungal activities, its inhibition rates against all selective tested pathogens reached more than 90 % at 50 μg/mL.

Keywords

Triazole Fluorine-containing compounds Antifungal activities Synthesis
Yang, S.-H., Zhai, Z.-W., & Zhang, S.-W. (2014). Synthesis and Antifungal Activities of Novel Fluorine-Containing Triazole Compounds. Asian Journal of Chemistry, 27(1), 173–176. https://doi.org/10.14233/ajchem.2015.16839
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