Isolation, Antioxidant and Antifungal Activities of Two Newly Reported Compounds from Bergenia ciliata

Farman Khan; Fatima Syed; Abdul Khabir; Abdur Rauf; Zia Ul Haq; Masood Afzal; Malik Aman Ullah; Ali Athar Hussain; Abdusubhan; M.J. Khurum; Shafiullah Khan

doi:10.14233/ajchem.2016.19797

Issue

Vol. 28 No. 9 (2016): Vol 28 Issue 9

Issue Published : June 1, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Isolation, Antioxidant and Antifungal Activities of Two Newly Reported Compounds from Bergenia ciliata

https://doi.org/10.14233/ajchem.2016.19797

Farman Khan

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Fatima Syed

Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan

Abdul Khabir

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Abdur Rauf

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Zia Ul Haq

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Masood Afzal

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Malik Aman Ullah

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Ali Athar Hussain

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Abdusubhan

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

M.J. Khurum

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Shafiullah Khan

Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Corresponding Author(s) : Shafiullah Khan

fermeon@gu.edu.pk

Asian Journal of Chemistry, Vol. 28 No. 9 (2016): Vol 28 Issue 9
Article Published : June 2, 2016

Abstract

Ethyl acetate fraction of Bergenia ciliata was subjected to various chromatographic techniques such as silica gel CC, size exclusion CC and reverse phase CC, which resulted in isolation of two new compounds from this specie. Modern spectroscopic techniques such as ¹H NMR, ¹³C NMR (BB and DEPT), 2D NMR, ESI and ESI-HR-MS were utilized to elucidate the structures of isolated secondary metabolites. Both the compounds A, B showed a remarkable fungicidal activity against Cladosporium cladosporioides in TLC bio-autography method. Compound B showed maximum activity (90.34 ± 0.81 %) against control drug.

Keywords

Bergenia ciliata Antioxidant Activity Antibacterial activity

Khan, F., Syed, F., Khabir, A., Rauf, A., Haq, Z. U., Afzal, M., … Khan, S. (2016). Isolation, Antioxidant and Antifungal Activities of Two Newly Reported Compounds from Bergenia ciliata. Asian Journal of Chemistry, 28(9), 1917–1920. https://doi.org/10.14233/ajchem.2016.19797

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References

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H.K. Lim, H.S. Kim, H.S. Choi, S. Oh and J. Choi, J. Ethnopharmacol., 72, 469 (2000); doi:10.1016/S0378-8741(00)00260-9.
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References

M. Rajbhandari, U. Wegner, T. Schopke, U. Lindequist and R. Mentel, Pharmazie, 58, 268 (2003).

E. Ahmed, M. Arshad, M. Ahmad, M. Saeed and M. Ishaque, Asian J. Plant Sci., 3, 410 (2004); doi:10.3923/ajps.2004.410.415.

S. Sinha, T. Murugesan, K. Maiti, J.R. Gayen, B. Pal, M. Pal and B.P. Saha, Fitoterapia, 72, 550 (2001a); doi:10.1016/S0367-326X(00)00322-1.

S.K. Uniyal, K.N. Singh, P. Jamwal and B. Lal, J. Ethnobiol. Ethnomed., 2, 14 (2006); doi:10.1186/1746-4269-2-14.

S. Sinha, T. Murugesan, K. Maiti, J.R. Gayen, M. Pal and B.P. Saha, J. Pharm. Pharmacol., 53, 193 (2001b); doi:10.1211/0022357011775398.

C.P. Bahl, R. Murari, M.R. Parthasarathy and T.R. Seshadri, Indian J. Chem., 12, 1038 (1974).

U.D. Chandrareddy, A.S. Chawla, D. Mundkinajeddu, R. Maurya and S.S. Handa, Phytochemistry, 47, 907 (1998); doi:10.1016/S0031-9422(97)00628-6.

S.V. Popov, G.Y. Popova, S.Y. Nikolaeva, V.V. Golovchenko and R.G. Ovodova, Phytother. Res., 19, 1052 (2005); doi:10.1002/ptr.1789.

T. Swarnalakshmi, M.G. Sethuraman, N. Sulochana and R. Arivudainambi, Curr. Sci., 53, 917 (1984).

M.A.F. Jahromi, J.P.N. Chansouria and A.B. Ray, Phytother. Res., 6, 180 (1992); doi:10.1002/ptr.2650060403.

S. Piacente, C. Pizza, N. Detommasi and N. Mahmood, J. Nat. Prod., 59, 565 (1996); doi:10.1021/np960074h.

H.-L. Pu, X. Huang, J.-H. Zhao and A. Hong, Planta Med., 68, 372 (2002); doi:10.1055/s-2002-26758.

H.K. Lim, H.S. Kim, H.S. Choi, S. Oh and J. Choi, J. Ethnopharmacol., 72, 469 (2000); doi:10.1016/S0378-8741(00)00260-9.

A.L. Homans and A. Fuchs, J. Chromatogr. A, 51, 327 (1970); doi:10.1016/S0021-9673(01)96877-3.

L. Rahalison, M. Hamburger, K. Hostettmann, M. Monod and E. Frenk, Phytochem. Anal., 2, 199 (1991); doi:10.1002/pca.2800020503.

W.J. Duan, J.Y. Yang, L.X. Chen, L.J. Zhang, Z.H. Jiang, X.D. Cai, X. Zhang and F.J. Qiu, Nat. Prod., 72, 1579 (2009); doi:10.1021/np9001898.

A. Braca, P.V. Kiem, P.H. Yen, N.X. Nhiem, T.H. Quang, N.X. Cuong and C.V. Minh, Fitoterapia, 79, 117 (2008); doi:10.1016/j.fitote.2007.11.001.

Issue

Vol. 28 No. 9 (2016): Vol 28 Issue 9

Isolation, Antioxidant and Antifungal Activities of Two Newly Reported Compounds from Bergenia ciliata

Corresponding Author(s) : Shafiullah Khan

Abstract

Keywords

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