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Synthesis and Biological Evaluation of N-Cinnamoyl and Mandelate Metformin Analogues
Corresponding Author(s) : K. Prabhu
Asian Journal of Chemistry,
Vol. 28 No. 9 (2016): Vol 28 Issue 9
Abstract
A series of N,N-dimethyl-N1-[3-(substituted phenyl)-1-oxo-2-propenyl]biguanides were synthesized by coupling a solution of metformin in pyridine with different cinnamoyl chloride derivatives in ether for 3 h in addition to synthesis of some five molecules of metformin-mandelates. All the synthesized cinnamoyl metformins and a few metformin-mandelates were characterized by IR, NMR and Mass spectroscopic techniques. All the synthesized compounds were also evaluated for their antioxidant activity by DPPH scavenging method and nitric oxide scavenging method. All the compounds exhibited good antioxidant activity.
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- F. Natella, M. Nardini, M. Di Felice and C. Scaccini, J. Agric. Food Chem., 47, 1453 (1999); doi:10.1021/jf980737w.
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- L.K. Dahle, E.G. Hill and R.T. Holman, Arch. Biochem. Biophys., 98, 253 (1962); doi:10.1016/0003-9861(62)90181-9.
References
F. Natella, M. Nardini, M. Di Felice and C. Scaccini, J. Agric. Food Chem., 47, 1453 (1999); doi:10.1021/jf980737w.
L. Liu, W.R. Hudgins, S. Shack, M.Q. Yin and D. Samid, Int. J. Cancer, 62, 345 (1995); doi:10.1002/ijc.2910620319.
M.L. Sharma and S. Kaur, J. Indian Chem. Soc., 84, 612 (2007).
M.-T. Huang, R.L. Chang, A.W. Wood, H.L. Newmark, J.M. Sayer, H. Yagi, D.M. Jerina and A.H. Conney, Oxford J. Life Sci., 6, 237 (1985).
L.K. Dahle, E.G. Hill and R.T. Holman, Arch. Biochem. Biophys., 98, 253 (1962); doi:10.1016/0003-9861(62)90181-9.