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Vol. 28 No. 9 (2016): Vol 28 Issue 9

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Synthesis, Characterization and Antibacterial Activity of Some Schiff Bases Prepared from 3-Hydroxy-2-naphthaldehyde and Phenyl Methanamine Derivatives

https://doi.org/10.14233/ajchem.2016.19811
Farman Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Muhammad Akram
Medicinal Botanic Centre, PCSIR Labs Complex Peshawer, Pakistan
Abdul Khabir
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Abdur Rauf
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Zia Ul Haq
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Masood Afzal
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Malik Aman Ullah
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Alaud-Din
Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan
Zakir Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Shafiullah Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Corresponding Author(s) : Shafiullah Khan

fermeon@gu.edu.pk

Asian Journal of Chemistry, Vol. 28 No. 9 (2016): Vol 28 Issue 9

Abstract

The synthesis of some new Schiff bases by condensing 3-hydroxy-2-naphthaldehyde and derivatives of phenyl methanamine i.e. 1-(4-chlorophenyl)methanamine, 1-(4-bromophenyl)methanamine, 1-(4-methylphenyl)methanamine and 1-(4-methoxyphenyl)methanamine is reported. These compounds are characterized on the basis of physical characteristics, micro-analytical data, 1H NMR, FTIR spectrum and electronic spectrum data. The Schiff base ligands have also been tested in vitro for their antibacterial activity. The experimental results suggested that Schiff base ligands are more potent in antibacterial activities.

Keywords

Schiff base Amine derivatives and aldehyde Spectroscopic study Biological activity
Khan, F., Akram, M., Khabir, A., Rauf, A., Haq, Z. U., Afzal, M., … Khan, S. (2016). Synthesis, Characterization and Antibacterial Activity of Some Schiff Bases Prepared from 3-Hydroxy-2-naphthaldehyde and Phenyl Methanamine Derivatives. Asian Journal of Chemistry, 28(9), 1925–1928. https://doi.org/10.14233/ajchem.2016.19811
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