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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Synthesis, Characterization, DNA Cleavage, Antimicrobial and Catalytic Studies of Tridentate (N3) Schiff Base Ligand and its Complexes with Transition Metal Ions

https://doi.org/10.14233/ajchem.2016.19800
S. Rajiv Gandhi
Department of Chemistry, Sri Balaji Chockalingam Engineering College, Arani-632 317, India
D. Sathis Kumar
PG and Research Department of Chemistry, C. Abdul Hakeem College (Autonomous), Melvisharam-632 509, India
R. Srinivasan
School of Bio-Sciences and Technology, VIT University, Vellore-632 014, India
A.K. Ibrahim Sheriff
PG and Research Department of Chemistry, C. Abdul Hakeem College (Autonomous), Melvisharam-632 509, India

Corresponding Author(s) : A.K. Ibrahim Sheriff

akmhi62@gmail.com; isisis_1@yahoo.co.in

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

Transition metal complexes of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) ions have been synthesized from cinnamaldehyde and diethylene-triamine. The complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility, FT-IR, electronic spectra, 1H NMR, 13C NMR, ESR, mass spectra and thermal studies. Their ligand field parameters have also been calculated. Hydrolysis of ethyl acetate has been studied by using the complexes as homogeneous catalysts. The DNA cleavage activities of Schiff base and its metal complexes have been monitored by agarose gel electrophoresis method in the presence of hydrogen peroxide. The antimicrobial activities of ligand and its metal complexes have been examined on the fungi Candida albicans and Aspergillus niger and bacteria Staphylococcus aureus, Escherichia coli and Bacillus cereus.

Keywords

Tridentate Schiff base ligand Ligand field parameters Hydrolysis of ester DNA cleavage Antimicrobial studies
Gandhi, S. R., Kumar, D. S., Srinivasan, R., & Sheriff, A. I. (2016). Synthesis, Characterization, DNA Cleavage, Antimicrobial and Catalytic Studies of Tridentate (N3) Schiff Base Ligand and its Complexes with Transition Metal Ions. Asian Journal of Chemistry, 28(8), 1721–1728. https://doi.org/10.14233/ajchem.2016.19800
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