Mass Spectrometry of Substituted Ethyl-4-anilinopyrazolo[3,4-b]pyridine-5-carboxylic Acids

Samia Khakwani; Samina Aslam; Mehrzadi Noureen Shahi; Tahir Maqbool; Alice M. Rolim Bernardino; Misbahul Ain Khan

doi:10.14233/ajchem.2016.19644

Issue

Vol. 28 No. 6 (2016): Vol 28 Issue 6

Issue Published : February 29, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Mass Spectrometry of Substituted Ethyl-4-anilinopyrazolo[3,4-b]pyridine-5-carboxylic Acids

https://doi.org/10.14233/ajchem.2016.19644

Samia Khakwani

Department of Chemistry, Women University Multan, Multan, Pakistan

Samina Aslam

Department of Chemistry, Women University Multan, Multan, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Mehrzadi Noureen Shahi

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Tahir Maqbool

Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan

Alice M. Rolim Bernardino

Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, Niteroi, RJ, 24020-150, Brazil

Misbahul Ain Khan

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; Research and Development Laboratories, Shafee-Reso, Ferozepur Road, Lahore, Pakistan

Corresponding Author(s) : Samia Khakwani

samiakhakwani@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 6 (2016): Vol 28 Issue 6
Article Published : February 29, 2016

Abstract

The mass spectral fragmentation of ethyl 4-anilinopyrazolo [3,4-b]pyridine-5-carboxylic acids are presented. The fragmentation is initiated by the elimination of CO₂ molecule followed by other fragments or elimination of water (m/z 18) which is then followed by successive loss of CO (m/z 28) and HCN (m/z 27).

Keywords

Fragmentations Aminopyrazoles Pyrazolopyridines Cyclizations

Khakwani, S., Aslam, S., Shahi, M. N., Maqbool, T., Rolim Bernardino, A. M., & Khan, M. A. (2016). Mass Spectrometry of Substituted Ethyl-4-anilinopyrazolo[3,4-b]pyridine-5-carboxylic Acids. Asian Journal of Chemistry, 28(6), 1258–1260. https://doi.org/10.14233/ajchem.2016.19644

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References

M. Chioua, E. Soriano, A. Samadi and J. Marco-Contelles, J. Heterocycl. Chem., 47, 861 (2010); doi:10.1002/jhet.403.
M. Williams, Prog. Neuropsychopharmacol. Biol. Psychiatry, 8, 209 (1984); doi:10.1016/0278-5846(84)90160-X.
R.B. Toche, D.C. Bhavsar, M.A. Kazi, S.M. Bagul and M.N. Jachak, J. Heterocycl. Chem., 47, 287 (2010); doi:10.1002/jhet.294.
M.N. Jachak, A.B. Avhale, B.K. Ghotekar, D.B. Kendre and B.T. Raghunath, J. Heterocycl. Chem., 45, 1221 (2008); doi:10.1002/jhet.5570450447.
R.B. Toche, B.K. Ghotekar, D.B. Kendre, M.A. Kazi and M.N. Jachak, J. Heterocycl. Chem., 45, 1711 (2008); doi:10.1002/jhet.5570450624.
P. Nagender, G.M. Reddy, R.N. Kumar, Y. Poornachandra, C.G. Kumar and B. Narsaiah, Bioorg. Med. Chem. Lett., 24, 2905 (2014); doi:10.1016/j.bmcl.2014.04.084.
T.M. Bare, C.D. McLaren, J.B. Campbell, J.W. Firor, J.F. Resch, C.P. Walters, A.I. Salama, B.A. Meiners and J.B. Patel, J. Med. Chem., 32, 2561 (1989); doi:10.1021/jm00132a011.
M.N. Jachak, A.B. Avhale, C.D. Tantak, R.B. Toche, C. Reidlinger and W. Stadlbauer, J. Heterocycl. Chem., 42, 1311 (2005); doi:10.1002/jhet.5570420710.
D.B. Kendre, R.B. Toche and M.N. Jachak, J. Heterocycl. Chem., 45, 1281 (2008); doi:10.1002/jhet.5570450504.
M.A. Khan and A. Mustafa, Pharmazie, 2, 813 (1986).
T. Maqbool, M.A. Khan, M.N. Khan, M.C. Elliott, M.A. Munawar, M. Nasrullah, A.W. Bhatti, A. Nazeer and W. Lin, Asian J. Chem., 25, 7715 (2013); doi:10.14233/ajchem.2013.14573A.
T. Maqbool, A. Nazeer, M.N. Khan, M.C. Elliott, M.A. Khan, M. Ashraf, M. Nasrullah, S. Arshad and M.A. Munawar, Asian J. Chem., 26, 2870 (2014); doi:10.14233/ajchem.2014.15918.
N. Perveen, S. Aslam, T. Maqbool, A.M.R. Bernadino, M.A. Munawar and M.A. Khan, Afinidad, 71, 566 (2014).
A.R.D. Azevedo, I.C.P.P. Frugulhetti, M.A. Khan, S. Khakwani and A.M.R. Bernardino, Heterocycl. Commun., 8, 47 (2002); doi:10.1515/HC.2002.8.1.47.
Q.N. Porter, J. Baldas, A. Weissbeger and E.C. Taylor, Wiley-Interscience, New York (1971.).

References

M. Chioua, E. Soriano, A. Samadi and J. Marco-Contelles, J. Heterocycl. Chem., 47, 861 (2010); doi:10.1002/jhet.403.

M. Williams, Prog. Neuropsychopharmacol. Biol. Psychiatry, 8, 209 (1984); doi:10.1016/0278-5846(84)90160-X.

R.B. Toche, D.C. Bhavsar, M.A. Kazi, S.M. Bagul and M.N. Jachak, J. Heterocycl. Chem., 47, 287 (2010); doi:10.1002/jhet.294.

M.N. Jachak, A.B. Avhale, B.K. Ghotekar, D.B. Kendre and B.T. Raghunath, J. Heterocycl. Chem., 45, 1221 (2008); doi:10.1002/jhet.5570450447.

R.B. Toche, B.K. Ghotekar, D.B. Kendre, M.A. Kazi and M.N. Jachak, J. Heterocycl. Chem., 45, 1711 (2008); doi:10.1002/jhet.5570450624.

P. Nagender, G.M. Reddy, R.N. Kumar, Y. Poornachandra, C.G. Kumar and B. Narsaiah, Bioorg. Med. Chem. Lett., 24, 2905 (2014); doi:10.1016/j.bmcl.2014.04.084.

T.M. Bare, C.D. McLaren, J.B. Campbell, J.W. Firor, J.F. Resch, C.P. Walters, A.I. Salama, B.A. Meiners and J.B. Patel, J. Med. Chem., 32, 2561 (1989); doi:10.1021/jm00132a011.

M.N. Jachak, A.B. Avhale, C.D. Tantak, R.B. Toche, C. Reidlinger and W. Stadlbauer, J. Heterocycl. Chem., 42, 1311 (2005); doi:10.1002/jhet.5570420710.

D.B. Kendre, R.B. Toche and M.N. Jachak, J. Heterocycl. Chem., 45, 1281 (2008); doi:10.1002/jhet.5570450504.

M.A. Khan and A. Mustafa, Pharmazie, 2, 813 (1986).

T. Maqbool, M.A. Khan, M.N. Khan, M.C. Elliott, M.A. Munawar, M. Nasrullah, A.W. Bhatti, A. Nazeer and W. Lin, Asian J. Chem., 25, 7715 (2013); doi:10.14233/ajchem.2013.14573A.

T. Maqbool, A. Nazeer, M.N. Khan, M.C. Elliott, M.A. Khan, M. Ashraf, M. Nasrullah, S. Arshad and M.A. Munawar, Asian J. Chem., 26, 2870 (2014); doi:10.14233/ajchem.2014.15918.

N. Perveen, S. Aslam, T. Maqbool, A.M.R. Bernadino, M.A. Munawar and M.A. Khan, Afinidad, 71, 566 (2014).

A.R.D. Azevedo, I.C.P.P. Frugulhetti, M.A. Khan, S. Khakwani and A.M.R. Bernardino, Heterocycl. Commun., 8, 47 (2002); doi:10.1515/HC.2002.8.1.47.

Q.N. Porter, J. Baldas, A. Weissbeger and E.C. Taylor, Wiley-Interscience, New York (1971.).

Issue

Vol. 28 No. 6 (2016): Vol 28 Issue 6

Mass Spectrometry of Substituted Ethyl-4-anilinopyrazolo[3,4-b]pyridine-5-carboxylic Acids

Corresponding Author(s) : Samia Khakwani

Abstract

Keywords

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