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Vol. 28 No. 5 (2016): Vol 28 Issue 5

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Transient and Steady State Characterization of Permeation Kinetics of Diclofenac through Ocular Tissue

https://doi.org/10.14233/ajchem.2016.19614
Rajaram Mohapatra
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 003, India
Subrata Mallick
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar-751 003, India

Corresponding Author(s) : Subrata Mallick

s_mallickin@yahoo.com; profsmallick@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 5 (2016): Vol 28 Issue 5

Abstract

Mechanism of permeation kinetics of a model drug has been studied through sheep cornea. Hydroxypropyl methylcellulose matrix film containing triethanolamine as plasticizer and benzalkonium chloride (BZC) as preservative was prepared by solvent casting technique. In this study, semi-empirical models, such as Higuchi and Korsmeyer-Peppas models were utilized for describing drug permeation kinetics. Mean transient time, mean steady state time and mean permeation time evaluated using statistical moment analysis were decreased with the increase of triethanolamine concentration in presence of benzalkonium chloride. Results of scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffractometry studies suggested the inhibition of the crystal growth of diclofenac in the film. Statistical moment analysis was employed for characterization of transient and steady state of kinetics of permeation. A correlation has also been established between the ex vivo permeation and in vitro dissolution of the formulations.

Keywords

Permeation kinetics Transient state Steady state Statistical moment analysis
Mohapatra, R., & Mallick, S. (2016). Transient and Steady State Characterization of Permeation Kinetics of Diclofenac through Ocular Tissue. Asian Journal of Chemistry, 28(5), 1149–1154. https://doi.org/10.14233/ajchem.2016.19614
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