Predict Water Solubility of Quinclorac by Henderson-Hasselbalch Equation under Different pH Solutions

Aixing Mao; Kailin Liu; Xiangying Liu; Lianyang Bai

doi:10.14233/ajchem.2016.19406

Issue

Vol. 28 No. 4 (2016): Vol 28 Issue 4

Issue Published : December 30, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Predict Water Solubility of Quinclorac by Henderson-Hasselbalch Equation under Different pH Solutions

https://doi.org/10.14233/ajchem.2016.19406

Aixing Mao

College of Plant Protection, Hunan Agricultural University, Changsha 410128, P.R. China

Kailin Liu

Collaborative Innovation Center of Farmland Weeds Control, Hunan University of Humanities, Science and Technology, Loudi, Hunan 417000, P.R. China; Biotechnology Research Center, Hunan Academy of Agricultural Sciences, Changsha 410125, P.R. China

Xiangying Liu

College of Plant Protection, Hunan Agricultural University, Changsha 410128, P.R. China

Lianyang Bai

College of Plant Protection, Hunan Agricultural University, Changsha 410128, P.R. China; Biotechnology Research Center, Hunan Academy of Agricultural Sciences, Changsha 410125, P.R. China

Corresponding Author(s) : Kailin Liu

kailin@hunau.net

Asian Journal of Chemistry, Vol. 28 No. 4 (2016): Vol 28 Issue 4
Article Published : December 30, 2015

Abstract

Solubility is one of the most important molecular physico-chemical parameters in herbicide research. However, the reported water solubility values of quinclorac were inconsistent. Since quinclorac is an ionizable pesticide, the water solubility of quinclorac was determined by saturation shake-flask method and the effect of pH on the solubility was observed. The results indicated that equilibrium solubility value of quinclorac in deionized water (20 °C) in the present study was 63.28 ± 1.57 mg/L, the reported solubility 62 to 72 mg/L of quinclorac in deionized water were reliable due to the error from different laboratory system, the solubility 0.065 mg/L might be in error. The equilibrium solubility increased from 3.61 to 10457.65 mg/L when the solution pH increased from 1.0 to 8.95. The Henderson-Hasselbalch equation was used to calculate the solubility in different pH buffer systems and found the Henderson-Hasselbalch equation can predict the pH-dependent solubility of quinclorac.

Keywords

Quinclorac Solubility pH Henderson-Hasselbalch equation

Mao, A., Liu, K., Liu, X., & Bai, L. (2015). Predict Water Solubility of Quinclorac by Henderson-Hasselbalch Equation under Different pH Solutions. Asian Journal of Chemistry, 28(4), 740–742. https://doi.org/10.14233/ajchem.2016.19406

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References

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References

M. Kah and C.D. Brown, Rev. Environ. Contam. Toxicol., 188, 149 (2006); doi:10.1007/978-0-387-32964-2_5.

C. Toni, C. Menezes, B. Clasen, J. Leitemperger, A. Pretto, M.B. Adaime, M. Leonardo Martins, R. Zanella and V.L. Loro, Ecotoxicol. Environ. Saf., 92, 27 (2013); doi:10.1016/j.ecoenv.2013.01.028.

Z. Woznica, J.D. Nalewaja, C.G. Messersmith and P. Milkowski, Weed Technol., 17, 582 (2003); doi:10.1614/0890-037X(2003)017[0582:QEAABA]2.0.CO;2.

L. Pareja, A. Perez-Parada, A. Aguera, V. Cesio, H. Heinzen and A.R. Fernandez-Alba, Chemosphere, 87, 838 (2012); doi:10.1016/j.chemosphere.2012.01.016.

C.A. Bergstrom, K. Luthman and P. Artursson, Eur. J. Pharm. Sci., 22, 387 (2004); doi:10.1016/j.ejps.2004.04.006.

U.S. EPA, EPA's Report on the Environment (ROE) (2008 Final Report), U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-07/045F (NTIS PB2008-112484) (2008).

FAO, Food and Agriculture Organization of the United Nations, Rome (2002).

A. Avdeef, Adv. Drug Deliv. Rev., 59, 568 (2007); doi:10.1016/j.addr.2007.05.008.

H.N. Po and N.M. Senozan, J. Chem. Educ., 78, 1499 (2001); doi:10.1021/ed078p1499.

G. Volgyi, E. Baka, K.J. Box, J.E. Comer and K. Takacs-Novak, Anal. Chim. Acta, 673, 40 (2010); doi:10.1016/j.aca.2010.05.022.

U.S. Food and Drug Administration, Rockville, MD, USA (2000).

M. Kah and C.D. Brown, J. Agric. Food Chem., 55, 2312 (2007); doi:10.1021/jf063048q.

Issue

Vol. 28 No. 4 (2016): Vol 28 Issue 4

Predict Water Solubility of Quinclorac by Henderson-Hasselbalch Equation under Different pH Solutions

Corresponding Author(s) : Kailin Liu

Abstract

Keywords

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