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Vol. 28 No. 4 (2016): Vol 28 Issue 4

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Synthesis, Characterization and Biological Activity of Some New Acetohydrazide Derivatives via 3,3'-Dimethylbenzidine

https://doi.org/10.14233/ajchem.2016.19545
Maysoon T. Tawfiq
Department of Chemistry, College of Education for Pure Science/Ibn-Al-Haitham, University of Baghdad, Baghdad, Iraq
Zainab A. Jabarah
Division of Basic Science, College of Agriculture, University of Baghdad, Baghdad, Iraq

Corresponding Author(s) : Maysoon T. Tawfiq

maysoontariqwaleed@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 4 (2016): Vol 28 Issue 4

Abstract

Schiff base (1): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidene)diacetic acid was obtained by condensation of 3,3'-dimethylbenzidine with glyoxalic acid in ethanol. The esterfication of 1 with ethanol in presence of sulfuric acid gave the ester (2): diphenyl-2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidene)diacetate, then converted this ester to the acid hydrazide by reaction with hydrazine hydrate in ethanol to gave (3): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidene)diacetohydrazide,which was reacted with substituted aldehydes in ethanol to give the corresponding Schiff bases (4 a,b,c): 2,2'-(3,3'-dimethylbiphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidine)bis(N'-(3-alkyl-4-hydroxybenzylidene)acetohydrazide). The prepared compounds were characterized by spectral methods and Schiff bases were screened for antibacterial activity.

Keywords

Heterocyclic compounds Schiff bases 3,3'-Dimethylbenzidine Glyoxylic acid Acid hydrazide Acetohydrazide
Tawfiq, M. T., & Jabarah, Z. A. (2015). Synthesis, Characterization and Biological Activity of Some New Acetohydrazide Derivatives via 3,3’-Dimethylbenzidine. Asian Journal of Chemistry, 28(4), 895–898. https://doi.org/10.14233/ajchem.2016.19545
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