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Vol. 28 No. 2 (2016): Vol 28 Issue 2

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Synthesis and Characterization of Novel Pyridine and Pyrimidine Based 1,2,4-Triazoles with Nematicidal Activity

https://doi.org/10.14233/ajchem.2016.19385
B. Satyanarayana Reddy
Department of Chemistry, Sri Krishnadevaraya University, Anathapuramu-515 003, India
B. Srinivasa Reddy
Hetero Drugs Limited, 7-2-A2, Industrial Estate, Sanath Nagar, Hyderabad-500 018, India
Chowdoji Rao
Department of Polymer Science, Sri Krishnadevaraya University, Ananthapuramu-515 003, India
M.C.S. Subha
Department of Chemistry, Sri Krishnadevaraya University, Anathapuramu-515 003, India

Corresponding Author(s) : B. Satyanarayana Reddy

bsnreddy83@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 2 (2016): Vol 28 Issue 2

Abstract

A series of new 2-phenyl-pyrido[2,3-e]-[1,2,4]triazolo[1,5-c]pyrimidine and its derivatives (5a-f) have been synthesized conveniently by cyclization of N-(4-imino-4H-pyrido[2,3-d]pyrimidin-3-yl)-benzamide and its derivatives (4a-f). The synthesis of title compounds commenced from commercially obtainable 2-amino-3-cyanopyridine (1) and by including N-(3-cyano-pyridin-2-yl)-formimidic acid ethyl ester (2) and benzoic acid N’-[(3-cyano-pyridin-2-ylimino)-methyl]hydrazide and its derivatives (3a-f) as intermediates. The chemical structures of all newly discovered compounds were established by IR, 1H NMR and 13C NMR, mass spectral data and elemental analysis. Further, the target compounds have been used to find their nematicidal activity towards two well known nematicides such as Ditylenchus myceliophagus and Caenorhabditis elegans.

Keywords

Pyridine Pyrimidine 1,2,4-Triazoles Nematicidal activity
Reddy, B. S., Reddy, B. S., Rao, C., & Subha, M. (2015). Synthesis and Characterization of Novel Pyridine and Pyrimidine Based 1,2,4-Triazoles with Nematicidal Activity. Asian Journal of Chemistry, 28(2), 405–409. https://doi.org/10.14233/ajchem.2016.19385
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