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Vol. 28 No. 1 (2016): Vol 28 Issue 1

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Phenols Catalyzed Biginelli Reactions: A Self Catalyzed Monastrol Protocol

https://doi.org/10.14233/ajchem.2016.19156
Abdul Ghafoor
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Naveed Sajid
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Asma Mukhtar
Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan
Shahid Ali
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Samina Aslam
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; Department of Chemistry, Woman University Multan, Multan, Pakistan
Mahrzadi Noureen Shahi
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Muhammad Adnan
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Misbahul Ain Khan
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan

Corresponding Author(s) : Abdul Ghafoor

agorg_ch@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 1 (2016): Vol 28 Issue 1

Abstract

A simple and efficient approach towards one step synthesis of various dihydropyrimidones and thiones (Biginelli reaction) was developed by using phenols as catalysts. The multicomponent reaction was conducted between aromatic aldehydes, active methylenes and urea (or thiourea) in an appropriate solvent. This seems to be a first example, where weak acids such as phenols have been employed with success.

Keywords

3,4-Dihydropyrimidones Phenols Biginelli reaction One pot reaction
Ghafoor, A., Sajid, N., Mukhtar, A., Ali, S., Aslam, S., Noureen Shahi, M., … Ain Khan, M. (2015). Phenols Catalyzed Biginelli Reactions: A Self Catalyzed Monastrol Protocol. Asian Journal of Chemistry, 28(1), 23–26. https://doi.org/10.14233/ajchem.2016.19156
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