Synthesis and Antiurease & Antioxidant Activities of Bis-Schiff Bases of Isophthalaldehyde

Fazal Rahim; Waseeq-ur-Rehamn; Muhammad Shehzad; Ajmal Khan; Muhammad Taha; Obaid-ur-Rahman Abid; Muhammad Tauseef Quereshi; Isfahan Tauseef; Wajid Rehman

doi:10.14233/ajchem.2016.19168

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Issue Published : October 5, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antiurease & Antioxidant Activities of Bis-Schiff Bases of Isophthalaldehyde

https://doi.org/10.14233/ajchem.2016.19168

Fazal Rahim

Depatment of Chemistry, Hazara University, Mansehra-21120, Pakistan

Waseeq-ur-Rehamn

Depatment of Chemistry, Hazara University, Mansehra-21120, Pakistan

Muhammad Shehzad

Department of Mathematics, Hazara University, Mansehra-21120, Pakistan

Ajmal Khan

Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan

Muhammad Taha

Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia; Faculty of Applied Science Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor, Malaysia Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia

Obaid-ur-Rahman Abid

Depatment of Chemistry, Hazara University, Mansehra-21120, Pakistan

Muhammad Tauseef Quereshi

Department of Physics, Hazara University, Mansehra 21120, Pakistan

Isfahan Tauseef

Department of Microbiology, Hazara University, Mansehra 21120, Pakistan

Wajid Rehman

Depatment of Chemistry, Hazara University, Mansehra-21120, Pakistan

Corresponding Author(s) : Fazal Rahim

fazalstar@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 1 (2016): Vol 28 Issue 1
Article Published : October 5, 2015

Abstract

Bis-Schiff bases of iosophthalaldehyde were synthesized by reacting isophthalaldehyde with hydrazine hydrate in 1:2 ratio in ethanol for 2-3 h under reflux. Product of first step was again reacted in 1:2 ratio with different aldehyde or acetophenone yielding bis-Schiff bases (1-16). All compounds were characterized by EI-MS and ¹H NMR. All analogs were tested against antioxidant and urease inhibition. Few compounds were found to showed potent antiurease and antioxidant potential.

Keywords

Schiff bases Isophthalaldehyde Urease inhibition Antioxidant potential

Rahim, F., Waseeq-ur-Rehamn, ., Shehzad, M., Khan, A., Taha, M., Abid, O.- ur-R., … Rehman, W. (2015). Synthesis and Antiurease & Antioxidant Activities of Bis-Schiff Bases of Isophthalaldehyde. Asian Journal of Chemistry, 28(1), 39–42. https://doi.org/10.14233/ajchem.2016.19168

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References

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References

C.M. Collins and S.E.F. D’Orazio, Mol. Microbiol., 9, 907 (1993); doi:10.1111/j.1365-2958.1993.tb01220.x.

B. Halliwell, Haemostasis, 23, 118 (1993); doi:10.1159/000216921.

M.G.L. Hertog, E.J.M. Feskens, D. Kromhout, M.G.L. Hertog, P.C.H. Hollman, M.G.L. Hertog and M.B. Katan, Lancet, 342, 1007 (1993); doi:10.1016/0140-6736(93)92876-U.

P.C.H. Holiman, M.G.L. Hertog and M.B. Katan, Food Chem., 57, 43 (1996); doi:10.1016/0308-8146(96)00065-9.

E.J. Hunt, C.E. Lester, P.A. Lester and R.L. Tackett, Life Sci., 69, 181 (2001); doi:10.1016/S0024-3205(01)01102-X.

M. Lateef, L. Iqbal, N. Fatima, K. Siddiqui, N. Afza, U.M. Zia and A. Mansoor, Pak. J. Pharm. Sci., 25, 99 (2012).

L.L. Mensor, F.S. Menezes, G.G. Leitao, A.S. Reis, T.C. Dos Santos, C.S. Coube and S.G. Leitao, Phytother. Res., 15, 127 (2001); doi:10.1002/ptr.687.

A.S. Meyer, M. Heinonen and E.N. Frankel, Food Chem., 61, 71 (1998); doi:10.1016/S0308-8146(97)00100-3.

H.L. Mobley and R.P. Hausinger, Microbiol. Rev., 53, 85 (1989).

H.L. Mobley, M.D. Island and R.P. Hausinger, Microbiol. Rev., 59, 451 (1995).

C. Montecucco and R. Rappuoli, Nat. Rev. Mol. Cell Biol., 2, 457 (2001).

A. Moure, J.M. Cruz, D. Franco, M. Dominguez, J. Sineiro, N.H. Dominguez, M.J. Núñez and J.C. Parajó, Food Chem., 72, 145 (2001); doi:10.1016/S0308-8146(00)00223-5.

R.L. Mulvaney, J.M. Bremner, in eds.: E.A. Paul and J.N. Ladd, Use of Urease and Nitrification inhibitors for Control of Urea Transformations in Soils, In: Soil Biochemistry, Marcel Dekker, New York, vol. 5, 153-186 (1981).

M.A. Pathak and P.C. Joshi, J. Invest. Dermatol., 80, 66 (1983); doi:10.1038/jid.1983.18.

J.W. Schmidley, Stroke, 21, 1086 (1990); doi:10.1161/01.STR.21.7.1086.

M. Zaman, S. Saggar, J.D. Blennerhassett and J. Singh, Soil Biol. Biochem., 41, 1270 (2009); doi:10.1016/j.soilbio.2009.03.011.

M.W. Weatherburn, Anal. Chem., 39, 971 (1967); doi:10.1021/ac60252a045.

W. Zhengping, O. Van Cleemput, P. Demeyer and L. Baert, Biol. Fertil. Soils, 11, 43 (1991); doi:10.1007/BF00335833.

M. Zia-ur-Rehman, J.A. Choudary, M.R.J. Elsegood, H.L. Siddiqui and K.M. Khan, Eur. J. Med. Chem., 44, 1311 (2009); doi:10.1016/j.ejmech.2008.08.002.

L.E. Zonia, N.E. Stebbins and J.C. Polacco, J. Plant Physiol., 107, 1097 (1995); doi:10.1104/pp.107.4.1097.

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Synthesis and Antiurease & Antioxidant Activities of Bis-Schiff Bases of Isophthalaldehyde

Corresponding Author(s) : Fazal Rahim

Abstract

Keywords

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