Template Synthesis of Macrocyclic Schiff Base Complexes of Transition Metal Ions and their Biological Activity

Vanita Goel; Rajesh Malhotra

doi:10.14233/ajchem.2016.20145

Issue

Vol. 28 No. 11 (2016): Vol 28 Issue 11

Issue Published : August 10, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Template Synthesis of Macrocyclic Schiff Base Complexes of Transition Metal Ions and their Biological Activity

https://doi.org/10.14233/ajchem.2016.20145

Vanita Goel

Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125 001, India

Rajesh Malhotra

Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125 001, India

Corresponding Author(s) : Vanita Goel

vanita_goel01@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11
Article Published : August 11, 2016

Abstract

The complexes of the type MLX₂ [where M = Zn(II), Co(II), Cu(II) and Ni(II); L is a condensation product of 1,3-dibenzoylbenzene and carbohydrazide/thiocarbohydrazide; X = Cl^–, CH₃COO^–] were synthesized using template method. These complexes were characterized by elemental analysis, spectral analysis (IR, NMR), magnetic moment measurements, molar conductivity, ESR studies and electronic measurements which indicated non electrolytic nature of complexes having distorted octahedral geometry. All the complexes were screened for antimicrobial activity against Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and phytopathogenic fungi (Candida albicans, Saccharomyces cerevisiae). Minimum inhibitory concentration (MIC) of these complexes was also determined and compared with standard antibiotics ciprofloxacin and amphotericin.

Keywords

1,3-Dibenzoylbenzene Carbohydrazide Thiocarbohydrazide Phytopathogenic fungi Template method

Goel, V., & Malhotra, R. (2016). Template Synthesis of Macrocyclic Schiff Base Complexes of Transition Metal Ions and their Biological Activity. Asian Journal of Chemistry, 28(11), 2571–2574. https://doi.org/10.14233/ajchem.2016.20145

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References

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M. Salavati-Niasari, M. Bazarganipour, M.R. Ganjali and P. Norouzi, Transition Met. Chem., 32, 9 (2007); doi:10.1007/s11243-006-0109-y.
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K.C. Gupta and A.K. Sutar, J. Coord. Rev., 252, 1420 (2008); doi:10.1016/j.ccr.2007.09.005.
R. Ahamad, R. Prasad and M.A. Quraishi, Corros. Sci., 52, 933 (2010); doi:10.1016/j.corsci.2009.11.016.
S. Chandra and K. Gupta, Transition Met. Chem., 27, 196 (2002); doi:10.1023/A:1013935602736.
S.M.M. Ali, M.A.K. Azad, M. Jesmin, S. Ahsan, M.M. Rahman, J.A. Khanam, M.N. Islam and S.M.S. Shahriar, Asian Pacific J. Trop. Biomed., 2, 438 (2012); doi:10.1016/S2221-1691(12)60072-0.
K. Chaubey and S.N. Pandeya, Int. J. Pharm. Technol. Res., 4, 590 (2012).
G. Kumar, D. Kumar, S. Devi, R. Johari and C.P. Singh, Eur. J. Med. Chem., 45, 3056 (2010); doi:10.1016/j.ejmech.2010.03.036.
S.M. Sondhi, N. Singh, A. Kumar, O. Lozach and L. Meijer, Bioorg. Med. Chem., 14, 3758 (2006); doi:10.1016/j.bmc.2006.01.054.
V.C. da Silveira, J.S. Luz, C.C. Oliveira, I. Graziani, M.R. Ciriolo and A.M.C. Ferreira, J. Inorg. Biochem., 102, 1090 (2008); doi:10.1016/j.jinorgbio.2007.12.033.
V.E. Kuz’min, A.G. Artemenko, V.P. Lozitsky, E.N. Muratov, A.S. Fedtchouk, N.S. Dyachenko, L.N. Nosach, T.L. Gridina, L.I. Shitikova, L.M. Mudrik, A.K. Mescheriakov, V.A. Chelombitko, A.I. Zheltvay and J.-J. Vanden Eynde, Acta Biochim. Pol., 49, 157 (2002).
R. Malhotra, S. Kumar, Jyoti, H.R. Singal and K.S. Dhindsa, Indian J. Chem., 39A, 421 (2000).
S. Kumar, R. Malhotra and K.S. Dhindsa, Polyhedron, 11, 1383 (1992); doi:10.1016/S0277-5387(00)83369-0.
S. Singh, R. Malhotra, A. Hooda and K.S. Dhindsa, Bull. Soc. Chim. Belg., 105, 108 (1996).
K.R. Aneja, C. Sharma and R. Joshi, Jundishapur J. Microbiol., 4, 175 (2011).
A. Nostro, A. Germano, V. D'Angelo, A. Marino and M.A. Cannatelli, Lett. Appl. Microbiol., 30, 379 (2000); doi:10.1046/j.1472-765x.2000.00731.x.
Q. Zeng, J. Sun, S. Gou, K. Zhou, J. Fang and H. Chen, Transition Met. Chem., 23, 371 (1998); doi:10.1023/A:1006994300484.
L.K. Gupta and S. Chandra, Transition Met. Chem., 31, 368 (2006); doi:10.1007/s11243-005-0002-0.
C. Lodeiro, R. Bastida, E. Bertolo, A. Macias and A. Rodriguez, Transition Met. Chem., 28, 388 (2003); doi:10.1023/A:1023672629805.
S. Chandra and L.K. Gupta, J. Indian Chem. Soc., 82, 454 (2005).
K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley Interscience Publication, New York (1978).
V.B. Rana, P. Singh, D.P. Singh and M.P. Teotia, Transition Met. Chem., 6, 36 (1981); doi:10.1007/BF01143465.
V.B. Rana, P. Singh, D.P. Singh and M.P. Teotia, Polyhedron, 1, 377 (1982); doi:10.1016/S0277-5387(00)80823-2.

References

N.E. Borisova, M.D. Reshetova and Y.A. Ustynyuk, Chem. Rev., 107, 46 (2007); doi:10.1021/cr0683616.

M. Salavati-Niasari, M. Bazarganipour, M.R. Ganjali and P. Norouzi, Transition Met. Chem., 32, 9 (2007); doi:10.1007/s11243-006-0109-y.

T. Aboul-Fadl, F.A. Mohammed and E.A. Hassan, Arch. Pharm. Res., 26, 778 (2003); doi:10.1007/BF02980020.

K.C. Gupta and A.K. Sutar, J. Coord. Rev., 252, 1420 (2008); doi:10.1016/j.ccr.2007.09.005.

R. Ahamad, R. Prasad and M.A. Quraishi, Corros. Sci., 52, 933 (2010); doi:10.1016/j.corsci.2009.11.016.

S. Chandra and K. Gupta, Transition Met. Chem., 27, 196 (2002); doi:10.1023/A:1013935602736.

S.M.M. Ali, M.A.K. Azad, M. Jesmin, S. Ahsan, M.M. Rahman, J.A. Khanam, M.N. Islam and S.M.S. Shahriar, Asian Pacific J. Trop. Biomed., 2, 438 (2012); doi:10.1016/S2221-1691(12)60072-0.

K. Chaubey and S.N. Pandeya, Int. J. Pharm. Technol. Res., 4, 590 (2012).

G. Kumar, D. Kumar, S. Devi, R. Johari and C.P. Singh, Eur. J. Med. Chem., 45, 3056 (2010); doi:10.1016/j.ejmech.2010.03.036.

S.M. Sondhi, N. Singh, A. Kumar, O. Lozach and L. Meijer, Bioorg. Med. Chem., 14, 3758 (2006); doi:10.1016/j.bmc.2006.01.054.

V.C. da Silveira, J.S. Luz, C.C. Oliveira, I. Graziani, M.R. Ciriolo and A.M.C. Ferreira, J. Inorg. Biochem., 102, 1090 (2008); doi:10.1016/j.jinorgbio.2007.12.033.

V.E. Kuz’min, A.G. Artemenko, V.P. Lozitsky, E.N. Muratov, A.S. Fedtchouk, N.S. Dyachenko, L.N. Nosach, T.L. Gridina, L.I. Shitikova, L.M. Mudrik, A.K. Mescheriakov, V.A. Chelombitko, A.I. Zheltvay and J.-J. Vanden Eynde, Acta Biochim. Pol., 49, 157 (2002).

R. Malhotra, S. Kumar, Jyoti, H.R. Singal and K.S. Dhindsa, Indian J. Chem., 39A, 421 (2000).

S. Kumar, R. Malhotra and K.S. Dhindsa, Polyhedron, 11, 1383 (1992); doi:10.1016/S0277-5387(00)83369-0.

S. Singh, R. Malhotra, A. Hooda and K.S. Dhindsa, Bull. Soc. Chim. Belg., 105, 108 (1996).

K.R. Aneja, C. Sharma and R. Joshi, Jundishapur J. Microbiol., 4, 175 (2011).

A. Nostro, A. Germano, V. D'Angelo, A. Marino and M.A. Cannatelli, Lett. Appl. Microbiol., 30, 379 (2000); doi:10.1046/j.1472-765x.2000.00731.x.

Q. Zeng, J. Sun, S. Gou, K. Zhou, J. Fang and H. Chen, Transition Met. Chem., 23, 371 (1998); doi:10.1023/A:1006994300484.

L.K. Gupta and S. Chandra, Transition Met. Chem., 31, 368 (2006); doi:10.1007/s11243-005-0002-0.

C. Lodeiro, R. Bastida, E. Bertolo, A. Macias and A. Rodriguez, Transition Met. Chem., 28, 388 (2003); doi:10.1023/A:1023672629805.

S. Chandra and L.K. Gupta, J. Indian Chem. Soc., 82, 454 (2005).

K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley Interscience Publication, New York (1978).

V.B. Rana, P. Singh, D.P. Singh and M.P. Teotia, Transition Met. Chem., 6, 36 (1981); doi:10.1007/BF01143465.

V.B. Rana, P. Singh, D.P. Singh and M.P. Teotia, Polyhedron, 1, 377 (1982); doi:10.1016/S0277-5387(00)80823-2.

Issue

Vol. 28 No. 11 (2016): Vol 28 Issue 11

Template Synthesis of Macrocyclic Schiff Base Complexes of Transition Metal Ions and their Biological Activity

Corresponding Author(s) : Vanita Goel

Abstract

Keywords

Full Article

Download Citation

References

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