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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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Protective Effect of Aqueous Leaves Antidote of Piper crocatum Against Lead Induced Oxidative Stress in Mice Liver

https://doi.org/10.14233/ajchem.2016.20049
Inyoman E. Lister
Department of Physiology, Faculty of Medicine, University of Prima Indonesia, Medan, North Sumatera, Indonesia
R. Zein
Laboratory of Environmental Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Science, Andalas University, Padang, West Sumatera, Indonesia
E. Yerizal
Department of Biochemistry, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia
E. Fachrial
Laboratory of Biomolecular, Faculty of Medicine, University of Prima Indonesia, Medan, North Sumatera, Indonesia
Y. Manjang
Department of Chemistry, Faculty of Mathematics and Natural Science, Andalas University, Padang, West Sumatera, Indonesia

Corresponding Author(s) : R. Zein

yysunpri@yahoo.com; mimiedison@yahoo.co.id

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

Present study investigated whether the Piper crocatum leaves antidote has given the protective effect against Pb(II) induced oxidative stress in mice liver. Oral administration of lead significantly increased serum hepatic markers (SGPT and SGOT), oxidative stress markers (malondialdehyde) and creatinine levels. Pre oral administration with Piper crocatum leaves antidote in lead intoxicated rats were significantly recovered the parameters. The histopathology analysis of liver section of experimental rats revealed that Piper crocatum leaves antidote exhibit the protective effect against lead(II) induced hepatic damage in mice.

Keywords

Piper crocatum Oxidative stress Serum hepatic markers Lead
Lister, I. E., Zein, R., Yerizal, E., Fachrial, E., & Manjang, Y. (2016). Protective Effect of Aqueous Leaves Antidote of Piper crocatum Against Lead Induced Oxidative Stress in Mice Liver. Asian Journal of Chemistry, 28(11), 2499–2501. https://doi.org/10.14233/ajchem.2016.20049
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