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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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Synthesis, Characterization and Biological Activity of Zn(II) Complexes with Dibasic Tridentate ONS-Donor Ligand

https://doi.org/10.14233/ajchem.2016.20039
B. Karpagam
Department of Chemistry, St. Michael College of Engineering and Technology, Kalayarkoil-630 551, India
S. Mathan Kumar
Department of Chemistry, K.S. Rangasamy College of Arts and Science (Autonomous), K.S.R. Kalvi Nagar, Tiruchengode-637 215, India
J. Rajesh
Department of Chemistry, Sethu Institute of Technology, Kariapatti-626 106, India
K. Dhahagani
Department of Chemistry, M.S.S. Wakf Board College, Madurai-625 020, India
G. Rajagopal
PG & Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur-641 602, India

Corresponding Author(s) : G. Rajagopal

rajagopal18@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

A new kind of zinc(II) complexes 1 and 2 with new Schiff base ligand (L) have been synthesized and characterized by 1H NMR, X-ray crystallography, IR and UV-visible spectroscopic studies. The trigonality index t of 0.63 for complex 2 indicates that the coordination geometry around zinc is intermediate between trigonal bipyramidal and square pyramidal geometries and is better described as trigonal bipyramidal distorted square based pyramid (TBDSBP) with zinc displaced above the N(2), N(4), O(1) and S(1) coordination plane and towards the elongated apical N(1) atom. The newly synthesized Schiff base ligand (L) and its Zn(II) complexes 1-2 were assayed for in vitro antibacterial activity against two Gram-positive bacteria strains (Stapholococcus aureus, Pseudomonas aeruginosa) and Gram-negative bacteria E. coli. The cancer cell line studies of the effect of the ligand (L) and its Zn(II) complexes 1-2 on a MCF-7 cancer cell line by an MTT assay indicates that the ligand (L) exhibits higher activity towards the metal complexes 1 and 2 when compared with cyclophosphamide as reference drug.

Keywords

Thiosemicarbazone ligand Zn(II) complexes Crystal structure Cell line studies
Karpagam, B., Kumar, S. M., Rajesh, J., Dhahagani, K., & Rajagopal, G. (2016). Synthesis, Characterization and Biological Activity of Zn(II) Complexes with Dibasic Tridentate ONS-Donor Ligand. Asian Journal of Chemistry, 28(11), 2487–2494. https://doi.org/10.14233/ajchem.2016.20039
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