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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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A Proportional Evaluation Based on Gender Dependence of Selected Elements in Hepatitis C Patients and Healthy Donors in Pakistan

https://doi.org/10.14233/ajchem.2016.19994
Musood Iqbal
Department of Chemistry, Mirpur University of Science & Technology, Mirpur-10250, Pakistan
Muhammad Aslam Mirza
Department of Chemistry, Mirpur University of Science & Technology, Mirpur-10250, Pakistan
M. Aziz Ch
Department of Chemistry, Mirpur University of Science & Technology, Mirpur-10250, Pakistan
Somia Qayyum
Department of Chemistry, Mirpur University of Science & Technology, Mirpur-10250, Pakistan

Corresponding Author(s) : Muhammad Aslam Mirza

aslamchem@must.edu.pk

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

The concentrations of selected elements (Ca, Cd, Co, Cr, Cu, Fe, K, Mn, Na and Ni) in the blood samples of chronic hepatitis C patients (men and women) and healthy donors were determined. The biological samples were determined by using flame atomic absorption under optimum spectrophotometric analytic conditions. In the blood samples of men hepatitis C virus patients, the dominant mean levels (mg/L) were found for Na, Ca, Fe and K, followed by Cr, Cd, Co, Cu, Ni and Mn. In women hepatitis C virus patients the higher concentrations were noted for Na, Fe, Ca and K, while Cu, Cd, Ni, Cr, Mn and Co were followed. In healthy subjects the relatively higher concentrations were observed for Ca, Na, Fe and K followed by very low value for Mn, Ni, Cu, Cr, Cd and Co. The data on element to element correlations in the blood samples of hepatitis C virus patients and healthy subjects exhibited significant variation among selected elements. The multivariate cluster analysis of the selected trace metals in the blood samples of hepatitis C virus patients and controls evidenced a marked disproportion, manifesting the imbalance in the essential elements (Ca, K, Fe and Na) by the toxic elements (Cd, Cr, Co and Ni). The distribution and correlation of trace elements in the blood samples of hepatitis C virus patients (men and women) revealed notable variations in comparison with healthy donors.

Keywords

Elements Hepatitis C Multivariate cluster analysis Flame atomic absorption
Iqbal, M., Mirza, M. A., Ch, M. A., & Qayyum, S. (2016). A Proportional Evaluation Based on Gender Dependence of Selected Elements in Hepatitis C Patients and Healthy Donors in Pakistan. Asian Journal of Chemistry, 28(11), 2415–2420. https://doi.org/10.14233/ajchem.2016.19994
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