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Synthesis, Characterization and Antitumor Studies of Two Copper(II) Schiff Base Complexes Derived from Glutathione and o-Vanillin

https://doi.org/10.14233/ajchem.2015.16681
Yaoyao Zhu
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Yuhua Fan
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Caifeng Bi
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Xia Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Pengfei Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Xingchen Yan
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China

Corresponding Author(s) : Caifeng Bi

bicaifeng301@163.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

Two new copper Schiff base complexes (Cu2C19H31N3O11S (1), Cu2(C18H23N3O8S) (C12H8N2)2) (2) [C18H23N3O8S = HL (Schiff base derived from glutathione and o-vanillin), C12H8N2 = 1,10-phenanthroline] were synthesized and characterizated by elemental analysis, IR spectroscopy, 1H NMR and thermogravimetric analysis. The test of cell proliferation observed that complex 2 binding with 1,10-phenanthroline are more potent apoptosis inducers in MDA MB 231 cells than complex 1. Furthermore, our study suggests that complex 2 is capable of inhibiting tumor cellular proteasome activity and induce cancer cell-specific apoptotic death.

Keywords

Glutathione Copper Schiff base Ternary complexes Antitumor
Zhu, Y., Fan, Y., Bi, C., Zhang, X., Zhang, P., & Yan, X. (2014). Synthesis, Characterization and Antitumor Studies of Two Copper(II) Schiff Base Complexes Derived from Glutathione and o-Vanillin. Asian Journal of Chemistry, 27(1), 47–50. https://doi.org/10.14233/ajchem.2015.16681
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