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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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Modified Biginelli Reaction: Synthesis of Pyrimidoquinoline Derivatives

https://doi.org/10.14233/ajchem.2019.21600
V. Nadaraj
Department of Chemistry, Tamilnadu College of Engineering, Coimbatore-641659, India
https://orcid.org/0000-0002-5113-416X
S. Thamarai Selvi
PG & Research Department of Chemistry, Government Arts College, Coimbatore-641018, India
M. Abirami
Department of Chemistry, Sri Ramakrishna Engineering College, Coimbatore-641022, India

Corresponding Author(s) : S. Thamarai Selvi

thamaraimohan@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

Compounds having quinolone and pyrimidine skeleton plays an important role in the medicinal chemistry. The objective of the present work was to modify the Biginelli reaction by using heterocylic ketones under microwave condition. We have demonstrated new synthetic route of quinolone fused 1,4-dipyrimidines by the reaction of 6-methyl-4-hyrdoxyquinolin-2(1H)-one (1), substituted aromatic aldehydes (2a-g) with phenyl urea (3). The structure of these newly synthesized compounds was characterized IR, NMR, Mass spectral and elemental analysis.

Keywords

Microwave Quinoline Beginelli reaction Pyrimido Aldehyde
Nadaraj, V., Selvi, S. T., & Abirami, M. (2019). Modified Biginelli Reaction: Synthesis of Pyrimidoquinoline Derivatives. Asian Journal of Chemistry, 31(6), 1243–1245. https://doi.org/10.14233/ajchem.2019.21600
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