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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Preparation Optimized and Sustained Release Behavior of Nifedipine-g-Polyglutamic Acid/Chitosan Nanoparticle

https://doi.org/10.14233/ajchem.2015.16885
Xia Ma
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China; Anhui Key Laboratory of Tobacco Chemistry (China Tobacco Anhui Industrial Co. Ltd., P.R. China
Min Ning
Anhui Key Laboratory of Tobacco Chemistry (China Tobacco Anhui Industrial Co. Ltd., P.R. China
Yuxi Chen
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China
Lei Ju
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China
Haiyan Yu
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China
Shiwen Chen
Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China

Corresponding Author(s) : Shiwen Chen

chenshiwen@126.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

In order to solve the problems caused by the low solubility of nifedipine (NF), such as, low bioavailability and short half-life, a novel drug delivery nanoparticle for sustained release of nifedipine was prepared and its sustained release behavior in systems of different pH were studied. The preparation of this nanoparticle was based on self-assembly of g-polyglutamic acid (g-PGA), which was extracted from the fermentation fluid that was produced by Bacillus subtilis and chitosan (CS) under normal pressure and temperature. When 2 mL of nifedipine/ethanol solution with a concentration of 0.5 g L-1 and 18 mL of g-PGA solution at pH of 8 and the concentration of 1 g L-1 were dropped into 2 mL chitosan solution at pH of 3 and the concentration of 0.4 g L-1 to prepare nanoparticle. The particle size (Z-Ave) and polydispersity index (PDI) were 232.2 nm and 0.2795, respectively. The ratio of drug-loading rate and encapsulation rate was 79.72 and 28.44 %, respectively. The accumulative release rate of drug would be well fitted Higuchi equation (Mt/M¥ = 0.1601t1/2 + 0.0486, R2 = 0.9731) and Peppas equation (Mt/M¥ = 0.2043t0.4376, R2 = 0.9816). Sustained release performance measurements indicated that there was remarkable sustained release effect of the NF-g-PGA/CS nanoparticle in circumstance of simulated intestinal fluid, while not so much sustained release effect in simulated gastric fluid. The NF-g-PGA/CS nanoparticle was an uniformly nano-sized typical sustained release preparation. This nanoparticle could be applied to clinical as sustained release preparation of nifedipine.

Keywords

Nifedipine-g-polyglutamic acid/chitosan nanoparticle (NF-g-PGA/CS) Sustained release Optimization RSM
Ma, X., Ning, M., Chen, Y., Ju, L., Yu, H., & Chen, S. (2014). Preparation Optimized and Sustained Release Behavior of Nifedipine-g-Polyglutamic Acid/Chitosan Nanoparticle. Asian Journal of Chemistry, 27(1), 233–238. https://doi.org/10.14233/ajchem.2015.16885
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