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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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Synthesis, Characterization and Anticonvulsant Potential of 2,5-Disubstituted 1,3,4-Oxadiazole Analogues

https://doi.org/10.14233/ajchem.2019.22061
Rajnish Kumar
Department of Pharmaceutical Chemistry, Noida institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park 2, Greater Noida-201306, India
https://orcid.org/0000-0001-7479-696X
Mohd. Mustaqeem Abdullah
Department of Pharmaceutical Chemistry, ANA Institute of Pharmaceutical Sciences and Research, Agras Road, Near Rubber Factory, National Highway 24, P.O. Bhitaura, Bareilly-243501, India

Corresponding Author(s) : Rajnish Kumar

mpharm.rajnish@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

A new series of compounds in which benzimidazole, oxadiazole and quinoline were incorporated, was synthesized and investigated for their anticonvulsant activity. Some of the newly synthesized compounds have shown good anticonvulsant activity. Significant anticonvulsant potency of the prepared derivatives has been evaluated by minimal electroshock and subcutaneous pentylenetetrazole animal model methods. The structure of synthesized compounds indicated that the introduction of strong electron donating groups like methoxy, amino and hydroxyl group and weak electron withdrawing halogen at phenyl ring attached to 1,3,4-oxadiazole moiety causes improvement in anticonvulsant activity. Locomotor behaviour was evaluated by actophotometer and toxicology study was also performed to evaluate their significance as required anticonvulsant compounds.

Keywords

Benzimidazole Quinoline 1,3,4-Oxadiazoles Anticonvulsant Locomotor activity
Kumar, R., & Abdullah, M. M. (2019). Synthesis, Characterization and Anticonvulsant Potential of 2,5-Disubstituted 1,3,4-Oxadiazole Analogues. Asian Journal of Chemistry, 31(6), 1389–1397. https://doi.org/10.14233/ajchem.2019.22061
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