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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Preparation and Performance Characteristics of Poly(g-glutamic acid)/Poly(vinyl alcohol) Hydrogels

https://doi.org/10.14233/ajchem.2015.17990
X. Ma
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China; Bright Dairy and Food Co. Ltd, Shanghai, P.R. China
M.M. Zhang
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, P.R. China
H.B. Mu
Bright Dairy and Food Co. Ltd, Shanghai, P.R. China
F. Hang
Bright Dairy and Food Co. Ltd, Shanghai, P.R. China
Z.M. Liu
Bright Dairy and Food Co. Ltd, Shanghai, P.R. China

Corresponding Author(s) : X. Ma

maxia0126@126.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

Poly(g-glutamic acid) (PGA) and poly(vinyl alcohol) (PVA) are polymers of great importance because of their many appealing characteristics specifically for various pharmaceutical and biomedical applications. Physically cross-linked hydrogel membranes composed of different amounts of poly(g-glutamic acid) and poly(vinyl alcohol) were prepared by applying freeze-thawing method. This freeze-thawing cycle was repeated for three consecutive cycles. Physicochemical properties of PGA-PVA membrane gel such as feeding ratio, swelling, water retention, enzymatic biodegradability and drug release were investigated. The influence of pH on the equilibrium swelling ratios of the hydrogels was investigated too. A higher poly(g-glutamic acid) content resulted in lower equilibrium swelling ratios. However, the water resistance and retention were improved. The biodegradation rate of the stimuli-sensitive hydrogels in the presence of enzyme was directly proportional to the poly(g-glutamic acid) content. Lysozyme was chosen as a model drug and loaded into the hydrogels. The in vitro drug release experiment was carried out at different pH values and the release data suggested that both the pH and poly(g-glutamic acid) content played important roles in the drug release behaviours of the hydrogels.

Keywords

Poly(g-glutamic acid) Poly(vinyl alcohol) Hydrogel
Ma, X., Zhang, M., Mu, H., Hang, F., & Liu, Z. (2014). Preparation and Performance Characteristics of Poly(g-glutamic acid)/Poly(vinyl alcohol) Hydrogels. Asian Journal of Chemistry, 27(1), 357–360. https://doi.org/10.14233/ajchem.2015.17990
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