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Vol. 25 No. 14 (2013): Vol 25 Issue 14

Copyright (c) 2013 Abdul Qayuum Ather1, Muhammad Ashraf6, Munawar Ali Munawar3, Muhammad Makshoof Athar3, Khalid M. Khan5, Noreen Aslam1, Misbahul Ain Khan1, Eliana Aparecida Silicz Bueno4, Muhammad Naeem Khan2, Faryal Chaudhry3, Syeda Abida Ejaz6

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Synthesis, Antibacterial and Antioxidant Properties of Pyrazolylpyridazines

https://doi.org/10.14233/ajchem.2013.14590A
Abdul Qayuum Ather1
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Faryal Chaudhry3
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Muhammad Naeem Khan2
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Eliana Aparecida Silicz Bueno4
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Misbahul Ain Khan1
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Noreen Aslam1
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Khalid M. Khan5
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Muhammad Makshoof Athar3
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Munawar Ali Munawar3
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Muhammad Ashraf6
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com
Syeda Abida Ejaz6
1Department of Chemistry, The Islamia Univerity of Bahawalpur, Bahawalpur, Pakistan 2Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan 3Institute of Chemistry, University of the Punjab, Quaid-e-azam Campus, Lahore, Pakistan 4Departamento de Quimica, Universidade Estadual de Londrina, Londrina, Parana, Brazil 5HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 6Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Corresponding author: E-mail: makshoof_athar@yahoo.com; changwani_1@yahoo.com

Corresponding Author(s) : Abdul Qayuum Ather1

Asian Journal of Chemistry, Vol. 25 No. 14 (2013): Vol 25 Issue 14

Abstract

A number of 6-chloro-3-(pyrazol-1'-yl) pyridazines were prepared from 3,6-dichloropyridazine via either reaction with hydrazine followed by reaction with appropriate reagents to develop the pyrazole or through a nucleophilic reaction with a pyrazole. Some electrophilic reactions gave the corresponding 4'-substituted pyrazolylpyridazines. All the compounds were tested for their in vitro antibacterial as well as their antioxidant properties.

Keywords

Nucleophilic substitutions Nitration Chlorination and bromination.
Qayuum Ather1, A., Chaudhry3, F., Naeem Khan2, M., Aparecida Silicz Bueno4, E., Ain Khan1, M., Aslam1, N., … Abida Ejaz6, S. (2013). Synthesis, Antibacterial and Antioxidant Properties of Pyrazolylpyridazines. Asian Journal of Chemistry, 25(14), 7743–7748. https://doi.org/10.14233/ajchem.2013.14590A
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