Complexes of Organyltellurium(IV) with Neutral [N,O] Donor Schiff Base Derived from Substituted Furfuraldehyde and Toluidine: Synthesis, Structural Characterization, Computational Studies and Biological Evaluation

Abstract

Organyltellurium(IV) complexes of Schiff base (MeFPT = 4-methyl-N-((5-methylfuran-2-yl)methylene)aniline) derived from condensation reaction of 5-methyl furan-2-carboxaldehyde with p-toluidine having formula of type MeFPT·RTeCl₃ and MeFPT·R₂TeCl₂ (R = 4-hydroxy-phenyl, 4-methoxyphenyl or 3-methyl-4-hydroxyphenyl) were reported. These complexes have been characterized by elemental analysis, IR, ¹H NMR, ¹³C NMR, UV-Vis, DFT, molecular modelling and mass spectra. The experimental data demonstrated that formed Schiff base complexes behaved as bidentate ligand with R₁TeCl₃ and R₂TeCl₂ chelated by neutral N and O atoms having distorted octahedral stereochemistry in all organyltellurium(IV) complexes. Schiff base and its organyltellurium(IV) complexes exhibited considerable biological activity. The antibacterial and antifungal activity have been carried out and the results were compared with some known antibiotics.