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Vol. 28 No. 10 (2016): Vol 28 Issue 10

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Effect of pH, Time and Temperature on Forced Degradation Studies of Quercetin in Presence of Polymers

https://doi.org/10.14233/ajchem.2016.19913
V.E. Pakade1
1Department of Chemistry, Private Bag x 021, Vaal University of Technology, Vanderbijlpark 1900, South Africa 2Molecular Sciences Institute, School of Chemistry, University of Witwatersrand, Private Bag 3, Johannesburg 2050, South Africa *Corresponding author: Tel: +27 16 9506629; E-mail: vus7pakade@yahoo.com
M. Lesaoana1
1Department of Chemistry, Private Bag x 021, Vaal University of Technology, Vanderbijlpark 1900, South Africa 2Molecular Sciences Institute, School of Chemistry, University of Witwatersrand, Private Bag 3, Johannesburg 2050, South Africa *Corresponding author: Tel: +27 16 9506629; E-mail: vus7pakade@yahoo.com
N.T. Tavengwa2
1Department of Chemistry, Private Bag x 021, Vaal University of Technology, Vanderbijlpark 1900, South Africa 2Molecular Sciences Institute, School of Chemistry, University of Witwatersrand, Private Bag 3, Johannesburg 2050, South Africa *Corresponding author: Tel: +27 16 9506629; E-mail: vus7pakade@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 10 (2016): Vol 28 Issue 10

Abstract

This study investigated the influence of pH, time and temperature on the degradation and adsorption of quercetin by molecularly imprinted polymer beads and non-imprinted polymers. Molecularly imprinted polymers and non-imprinted polymers were prepared by precipitation polymerization using acrylamide and 4-vinylpyridine co-monomers and ethylene glycol dimethacrylate (EGDMA) cross-linker. The polymers were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and elemental analysis. Adsorption/degradation studies were carried out at varying pH, time and temperature. Maximum quercetin adsorption by molecularly imprinted polymer and non-imprinted polymer was observed at pH 4 (20 °C) and pH 6 (60 °C). Highest degradation in blank solutions was seen at pH 2 at 60 °C after 120 h. HPLC analysis showed the presence of degradation products. Quercetin was released back into solution in some instances which arose a potential of the prepared molecularly imprinted polymers in being used as future prospect in drug delivery systems.

Keywords

Quercetin Adsorption Degradation Imprinted polymer.
Pakade1, V., Lesaoana1, M., & Tavengwa2, N. (2016). Effect of pH, Time and Temperature on Forced Degradation Studies of Quercetin in Presence of Polymers. Asian Journal of Chemistry, 28(10), 2181–2187. https://doi.org/10.14233/ajchem.2016.19913
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