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Vol. 28 No. 10 (2016): Vol 28 Issue 10

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Green Synthesis of Isoxazoline Derivatives Using Microwave Irradiation and Their Antifungal Activity

https://doi.org/10.14233/ajchem.2016.19900
Akhil Goyal1
1Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, India 2Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India *Corresponding author: E-mail: jimmygoyal51@gmail.com
Sunita Sharma2
1Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, India 2Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India *Corresponding author: E-mail: jimmygoyal51@gmail.com
Jyoti Gaba1
1Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, India 2Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India *Corresponding author: E-mail: jimmygoyal51@gmail.com
Harleen Kaur2
1Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, India 2Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, India *Corresponding author: E-mail: jimmygoyal51@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 10 (2016): Vol 28 Issue 10

Abstract

Microwave irradiation method was used for synthesis of isoxazolines. Claisen Schmidt reaction of different aromatic aldehydes with acetanilide gave acrylamides (1a-1h) which on further reaction with hydroxylamine hydrochloride (in the presence of sodium hydroxide) afforded isoxazolines (2a-2h). Physical data of all the synthesized compounds were recorded. Isoxazolines were characterized by their IR and 1H NMR spectra. All the synthesized isoxazolines were screened for their antifungal activity against fungi namely Drechslera maydis and Rhizoctonia solani isolated from maize. Isoxazolines having chloro substitution on benzene ring found to be most effective followed by fluoro and nitro substituted compounds. None of the compound was registered as effective as Bavistin.

Keywords

Acrylamides Antifungal activity Isoxazolines ED50.
Goyal1, A., Sharma2, S., Gaba1, J., & Kaur2, H. (2016). Green Synthesis of Isoxazoline Derivatives Using Microwave Irradiation and Their Antifungal Activity. Asian Journal of Chemistry, 28(10), 2169–2172. https://doi.org/10.14233/ajchem.2016.19900
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