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Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

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Virtual Screening, DNA Strapping and Antimicrobial Investigation of Mixed Ligand Transition Metal Complexes

https://doi.org/10.14233/ajchem.2023.27874
Nazeer Mohamed Nasar
Research Department of Chemistry, VHNSN College (Autonomous) (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar-626001, India
https://orcid.org/0000-0003-2401-6288
Michael Samuel
Research Department of Chemistry, VHNSN College (Autonomous) (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar-626001, India
https://orcid.org/0000-0003-4672-5376
Porkodi Jayaraman
Post Graduate and Research Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Sivakasi-626123, India
https://orcid.org/0000-0002-6298-9761
Freeda Selva Sheela
Research Department of Chemistry, VHNSN College (Autonomous) (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar-626001, India
https://orcid.org/0000-0003-4511-6608
Natarajan Raman
Research Department of Chemistry, VHNSN College (Autonomous) (Affiliated to Madurai Kamaraj University, Madurai), Virudhunagar-626001, India
https://orcid.org/0000-0003-1788-6349

Corresponding Author(s) : Natarajan Raman

ramchem1964@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

Abstract

To obtain the highest level of biological effectiveness, four transition metal viz., Cu(II), Zn(II), Co(II) and Ni(II) complexes viz. were synthesized using Schiff base obtained by the condensation reaction of o-phenylene diamine, 4-chlorobenzaldehyde and a co-ligand (malonic acid). Elemental analysis and other spectroscopic methods were used to identify them. All the synthesized metal(II) complexes have a square planar geometry, according to the physico-chemical analyses. The antibacterial properties of the ligand and its metal(II) complexes on various microorganisms were also studied. SWISS-ADME online freeware was used to screen these compounds for drug-like action and pharmacokinetic research. Furthermore, UV absorption analyses and viscosity titrations were employed to test the efficacy of the synthesised metal complexes as DNA nucleases, and the results are consistent with an intercalative binding mechanism. The outcomes of molecular docking research on the COVID-19 virus and cancer DNA are fascinating.

Keywords

Malonic acid Intercalation DNA binding Antimicrobial activity In silico Molecular docking
Nasar, N. M., Samuel, M., Jayaraman, P., Sheela, F. S., & Raman, N. (2023). Virtual Screening, DNA Strapping and Antimicrobial Investigation of Mixed Ligand Transition Metal Complexes. Asian Journal of Chemistry, 35(6), 1491–1499. https://doi.org/10.14233/ajchem.2023.27874
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