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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 Humaira Parveen

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Novel Ferrocenyl-substituted Organometallics with Pyrimidine Moiety as Potent Antiprotozoal Agents: Synthesis, Characterization and in Silico Evaluation

Ferrocenyl substituted organometallics/heterocyclic compounds as potent antiprotozoal agents
https://doi.org/10.14233/ajchem.2023.28093
Humaira Parveen
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk-71491, Kingdom of Saudi Arabia
https://orcid.org/0000-0001-8365-0014
MOHAMMAD YOUNUS WANI
Department of Chemistry, College of Science, University of Jeddah, 21589 Jeddah, Kingdom of Saudi Arabia
https://orcid.org/0000-0002-1838-1337
FATIMAH A. ALOTAIBI
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk-71491, Kingdom of Saudi Arabia
https://orcid.org/0000-0003-2417-7735
SAYEED MUKHTAR
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk-71491, Kingdom of Saudi Arabia
UZMA FARIDI
Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk-71491, Kingdom of Saudi Arabia
https://orcid.org/0000-0002-5263-6065

Corresponding Author(s) : Humaira Parveen

h.nabi@ut.edu.sa

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

Metallodrugs have been extensively used in modern research to design and synthesize new core drug molecules. In search of new leads in protozoal chemotherapy, we have synthesized novel ferrocene-substituted pyrimidine-based organometallic compounds and thoroughly investigated their ADMET [Absorption, distribution, metabolism, excretion and toxicity] and pharmacokinetic properties. The compounds exhibited excellent solubility potential, with favourable permeability and absorption characteristics. They demonstrated low toxicity, as indicated by clearance values and oral toxicity measurements. Molecular docking studies revealed strong interactions with the target site, surpassing the performance of reference drugs metronidazole and ornidazole. Overall, these organometallic compounds possess desirable ADMET profiles, meet Lipinski's criteria, and exhibit promising drug-likeness properties, positioning them as potential leads for the development of effective antiprotozoal agents.

Keywords

Ferrocene Substituted organometallics Pharmacokinetic Molecular docking studies Antiprotozoal Chemotherapy
Parveen, H., YOUNUS WANI, M., ALOTAIBI, F. A., MUKHTAR, S., & FARIDI, U. (2023). Novel Ferrocenyl-substituted Organometallics with Pyrimidine Moiety as Potent Antiprotozoal Agents: Synthesis, Characterization and in Silico Evaluation : Ferrocenyl substituted organometallics/heterocyclic compounds as potent antiprotozoal agents. Asian Journal of Chemistry, 35(9), 2189–2196. https://doi.org/10.14233/ajchem.2023.28093
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